Overcoming tumor resistance mechanisms in CAR-NK cell therapy
A Valeri, A García-Ortiz, E Castellano… - Frontiers in …, 2022 - frontiersin.org
Despite the impressive results of autologous CAR-T cell therapy in refractory B
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …
Engineering the next generation of CAR-NK immunotherapies
A Biederstädt, K Rezvani - International journal of hematology, 2021 - Springer
Over the past few years, cellular immunotherapy has emerged as a novel treatment option
for certain forms of hematologic malignancies with multiple CAR-T therapies now routinely …
for certain forms of hematologic malignancies with multiple CAR-T therapies now routinely …
Chimeric antigen receptor-engineered natural killer (CAR NK) cells in cancer treatment; recent advances and future prospects
Natural Killer (NK) cells are critical members of the innate immunity lymphocytes and have a
critical role in host defense against malignant cells. Adoptive cell therapy (ACT) using …
critical role in host defense against malignant cells. Adoptive cell therapy (ACT) using …
Chimeric antigen receptor engineered natural killer cells for cancer therapy
Y Zhang, W Zhou, J Yang, J Yang, W Wang - Experimental Hematology & …, 2023 - Springer
Natural killer (NK) cells, a unique component of the innate immune system, are inherent
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …
Feeder cells at the interface of natural killer cell activation, expansion and gene editing
Genome engineered natural killer (NK) cell therapies are emerging as a promising cancer
immunotherapy platform with potential advantages and remaining uncertainties. Feeder …
immunotherapy platform with potential advantages and remaining uncertainties. Feeder …
CRISPR gene editing of human primary NK and T cells for cancer immunotherapy
E Elmas, N Saljoughian… - Frontiers in …, 2022 - frontiersin.org
Antitumor activity of immune cells such as T cells and NK cells has made them auspicious
therapeutic regimens for adaptive cancer immunotherapy. Enhancing their cytotoxic effects …
therapeutic regimens for adaptive cancer immunotherapy. Enhancing their cytotoxic effects …
A bio‐liposome activating natural killer cell by illuminating tumor homogenization antigen properties
X Yang, J Bian, Z Wang, M He, Y Yang, Q Li… - Advanced …, 2023 - Wiley Online Library
Natural killer (NK) cell therapies, primarily based on chimeric antigen receptor NK cells
(CAR‐NK), have been developed and applied clinically for therapeutic treatment of patients …
(CAR‐NK), have been developed and applied clinically for therapeutic treatment of patients …
CAR NK cell therapy in hematologic malignancies and solid tumors; obstacles and strategies to overcome the challenges
Adoptive cell treatment (ACT) utilizing chimeric antigen receptors (CAR) diverts the
specificity of safe cells against a target-specific antigen and portrays exceptional potential for …
specificity of safe cells against a target-specific antigen and portrays exceptional potential for …
Optimizing NK cell-based immunotherapy in myeloid leukemia: abrogating an immunosuppressive microenvironment
NM Kaweme, F Zhou - Frontiers in Immunology, 2021 - frontiersin.org
Natural killer (NK) cells are prominent cytotoxic and cytokine-producing components of the
innate immune system representing crucial effector cells in cancer immunotherapy …
innate immune system representing crucial effector cells in cancer immunotherapy …
Genetic manipulation approaches to enhance the clinical application of NK cell-based immunotherapy
Natural killer (NK) cells are a subset of cytotoxic lymphocytes within the innate immune
system. While they are naturally cytotoxic, genetic modifications can enhance their tumor …
system. While they are naturally cytotoxic, genetic modifications can enhance their tumor …