Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Alzheimer's disease (AD) is the most common cause of dementia in older adults.
Neuropathological and imaging studies have demonstrated a progressive and stereotyped …

Currently, numerous associations between genetic polymorphisms and various diseases
have been characterized through the Genome-Wide Association Studies. Majority of the …

Cofactors interacting with PPARγ can regulate adipogenesis and adipocyte metabolism by
modulating the transcriptional activity and selectivity of PPARγ signaling. ZFP407 was …

Background Transposable elements play a critical role in maintaining genome architecture
during neurodevelopment. Short Interspersed Nuclear Elements (SINEs), a major subtype of …

Sequence motifs are an important concept in molecular biology, as specific repeating
patterns in DNA, RNA and proteins form the basis of biological regulation. Identifying and …

Lungs, essential for terrestrial vertebrates and present in bony fishes but absent in
cartilaginous fishes, provide an ideal model for studying organ origination. Our study …

Identifying the causal variants and mechanisms that drive complex traits and diseases
remains a core problem in human genetics. The majority of these variants have individually …

Understanding how regulatory DNA elements shape gene expression across individual
cells is a fundamental challenge in genomics. Joint RNA-seq and epigenomic profiling …

Arthropod-borne viruses (arboviruses) such as dengue virus (DENV) and Zika virus (ZIKV)
pose a significant threat to global health. Novel approaches to control the spread of …