The salience network (SN) plays a central role in cognitive control by integrating sensory
input to guide attention, attend to motivationally salient stimuli and recruit appropriate …

A growing preclinical and clinical body of work on the effects of chronic drug use and drug
addiction has extended the scope of inquiry from the putative reward-related subcortical …

Impulsivity is strongly associated with substance use disorders (SUDs). Our review
discusses impulsivity as an underlying vulnerability marker for SUDs, and treatment of co …

This study relies on knowledge regarding the neuroplasticity of dual-system components
that govern addiction and excessive behavior and suggests that alterations in the grey …

This chapter begins with a summary of the initial findings on the effects of insula lesions on
smoking behavior as well as more recent human‐lesion studies that replicate and extend …

Background: Cocaine use disorder is associated with cognitive deficits. However, the
literature remains somewhat ambiguous with respect to which distinct cognitive functions are …

Objective Suicide is a major public health concern as each year 30000 people die by
suicide in the USA alone. In the teenage population, it is the second leading cause of death …

This article provides an overview of the history of substance use and misuse and chronicles
the long shared history humans have had with psychoactive substances, including alcohol …

Since the first study in stimulant-dependent individuals using structural MRI was published
fifteen years ago, much evidence has accumulated on brain abnormalities associated with …

Recent animal studies demonstrate that compulsive cocaine seeking strongly reduces
prelimbic frontal cortex activity, while optogenetic stimulation of this brain area significantly …