Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to
tackle disease-causing proteins that have historically been highly challenging to target with …

Proteolysis-targeting chimeras (PROTACs) and related molecules that induce targeted
protein degradation by the ubiquitin–proteasome system represent a new therapeutic …

Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad
biological processes through target-specific ubiquitylation. Our knowledge of this system …

INTRODUCTION MicroRNAs (miRNAs) are a class of highly conserved small regulatory
RNAs. After loading into Argonaute (AGO) proteins, miRNAs promote the degradation and …

The ubiquitin proteasome pathway is responsible for most of the protein degradation in
mammalian cells. Rates of degradation by this pathway have generally been assumed to be …

Mutations in the tumor suppressor SPOP (speckle-type POZ protein) cause prostate, breast,
and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and …

Eukaryotic cell biology depends on cullin–RING E3 ligase (CRL)-catalysed protein
ubiquitylation, which is tightly controlled by the modification of cullin with the ubiquitin-like …

The ubiquitin system has become synonymous with the modification of lysine residues.
However, the substrate scope and diversity of the conjugation machinery have been …

E3 ligases are typically classified by hallmark domains such as RING and RBR, which are
thought to specify unique catalytic mechanisms of ubiquitin transfer to recruited substrates …

RING E3s comprise the largest family of ubiquitin (UB) and ubiquitin-like protein (UBL)
ligases. RING E3s typically promote UB or UBL transfer from the active site of an associated …