The current landscape of immunotherapy for pediatric brain tumors
EI Hwang, EJ Sayour, CT Flores, G Grant… - Nature Cancer, 2022 - nature.com
Pediatric central nervous system tumors are the most common solid malignancies in
childhood, and aggressive therapy often leads to long-term sequelae in survivors, making …
childhood, and aggressive therapy often leads to long-term sequelae in survivors, making …
New developments in the pathogenesis, therapeutic targeting, and treatment of pediatric medulloblastoma
Simple Summary Medulloblastoma is the most common pediatric brain tumor, comprising
one-third of all pediatric brain tumors, and originating in the posterior fossa of the brain. The …
one-third of all pediatric brain tumors, and originating in the posterior fossa of the brain. The …
A neurodevelopmental epigenetic programme mediated by SMARCD3–DAB1–Reelin signalling is hijacked to promote medulloblastoma metastasis
How abnormal neurodevelopment relates to the tumour aggressiveness of medulloblastoma
(MB), the most common type of embryonal tumour, remains elusive. Here we uncover a …
(MB), the most common type of embryonal tumour, remains elusive. Here we uncover a …
Drug repurposing for glioblastoma and current advances in drug delivery—a comprehensive review of the literature
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with an
extremely poor prognosis. There is a dire need to develop effective therapeutics to …
extremely poor prognosis. There is a dire need to develop effective therapeutics to …
The neurodevelopmental and molecular landscape of medulloblastoma subgroups: Current targets and the potential for combined therapies
Simple Summary Medulloblastoma is the most common malignant brain tumor in the
pediatric population. Despite the utilization of aggressive treatment modalities, including …
pediatric population. Despite the utilization of aggressive treatment modalities, including …
[HTML][HTML] Effect of anti-COVID-19 drugs on patients with cancer
W Huang, W Liu, T Yu, Z Zhang, L Zhai… - European Journal of …, 2024 - Elsevier
The clinical treatment of patients with cancer who are also diagnosed with coronavirus
disease (COVID-19) has been a challenging issue since the outbreak of COVID-19 …
disease (COVID-19) has been a challenging issue since the outbreak of COVID-19 …
Identification of Proteins and Genes Associated with Hedgehog Signaling Pathway Involved in Neoplasm Formation Using Text-Mining Approach
NY Biziukova, SM Ivanov… - Big Data Mining and …, 2023 - ieeexplore.ieee.org
Analysis of molecular mechanisms that lead to the development of various types of tumors is
essential for biology and medicine, because it may help to find new therapeutic …
essential for biology and medicine, because it may help to find new therapeutic …
eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production
JC Mars, B Culjkovic-Kraljacic, KLB Borden - Nucleus, 2024 - Taylor & Francis
The eukaryotic translation initiation factor eIF4E acts as a multifunctional factor that
simultaneously influences mRNA processing, export, and translation in many organisms. Its …
simultaneously influences mRNA processing, export, and translation in many organisms. Its …
EXTH-79. HIJACKING A NEURODEVELOPMENTAL EPIGENOMIC PROGRAM IN METASTATIC DISSEMINATION OF MEDULLOBLASTOMA
Normal brain development relies on precise genetic and epigenetic spatiotemporal
regulation of gene expression. How dysregulation of neurodevelopment relates to …
regulation of gene expression. How dysregulation of neurodevelopment relates to …
Combination Therapy of Temozolomide, Ribavirin and Interferon-Beta for Glioblastoma In Vivo
Y Genki, Y Shun, S Emiko - 日大医学雑誌, 2023 - jstage.jst.go.jp
We have investigated the potential of the antiviral drugs ribavirin (RBV) and interferon-beta
(IFN-β) for drug repositioning and have described the antitumor effect of combination …
(IFN-β) for drug repositioning and have described the antitumor effect of combination …