The molecular mechanisms that underlie the immune biology of anti-drug antibody formation following treatment with monoclonal antibodies
A Vaisman-Mentesh, M Gutierrez-Gonzalez… - Frontiers in …, 2020 - frontiersin.org
Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …
however, the repeated administration of mAbs can be highly immunogenic. Drug …
HIV-1 vaccines based on antibody identification, B cell ontogeny, and epitope structure
PD Kwong, JR Mascola - Immunity, 2018 - cell.com
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike
glycoprotein antigenic sites will inform the development of improved therapeutics. We …
glycoprotein antigenic sites will inform the development of improved therapeutics. We …
Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
dramatically expedited global vaccine development efforts,–, most targeting the viral …
dramatically expedited global vaccine development efforts,–, most targeting the viral …
[HTML][HTML] Human neutralizing antibodies elicited by SARS-CoV-2 infection
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a global health emergency that …
respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a global health emergency that …
Cryo-EM structures of SARS-CoV-2 spike without and with ACE2 reveal a pH-dependent switch to mediate endosomal positioning of receptor-binding domains
The SARS-CoV-2 spike employs mobile receptor-binding domains (RBDs) to engage the
human ACE2 receptor and to facilitate virus entry, which can occur through low-pH …
human ACE2 receptor and to facilitate virus entry, which can occur through low-pH …
[HTML][HTML] Maturation and persistence of the anti-SARS-CoV-2 memory B cell response
Memory B cells play a fundamental role in host defenses against viruses, but to date, their
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
Observed Antibody Space: A diverse database of cleaned, annotated, and translated unpaired and paired antibody sequences
The antibody repertoires of individuals and groups have been used to explore disease
states, understand vaccine responses, and drive therapeutic development. The arrival of B …
states, understand vaccine responses, and drive therapeutic development. The arrival of B …
Precursor frequency and affinity determine B cell competitive fitness in germinal centers, tested with germline-targeting HIV vaccine immunogens
How precursor frequencies and antigen affinities impact interclonal B cell competition is a
particularly relevant issue for candidate germline-targeting HIV vaccine designs because of …
particularly relevant issue for candidate germline-targeting HIV vaccine designs because of …
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
Induction of broadly neutralizing antibodies (bnAbs) is a major HIV vaccine goal. Germline-
targeting immunogens aim to initiate bnAb induction by activating bnAb germline precursor …
targeting immunogens aim to initiate bnAb induction by activating bnAb germline precursor …