Abstract Systems-based based approaches have begun to shed light on extrinsic factors that
contribute to immune system variation. Among these, CMV (HHV-5, a β-herpesvirus) …

In the year 2000, cytomegalovirus was identified as a risk factor for mortality in a seminal
study of octogenarian residents in Sweden. This finding triggered a wave of additional …

Memory inflation, as a term, has been used for 15 years now to describe the longitudinal
development of stable, expanded CD 8+ T memory pools with a distinct phenotype and …

Understanding how the T cell memory response directed towards human cytomegalovirus
(HCMV) develops and changes over time while the virus persists is important. Whilst HCMV …

Cytomegalovirus (CMV) is a ubiquitous herpes virus that infects most humans, thereafter
persisting lifelong in tissues of the host. It is a known pathogen in immunosuppressed …

Long-lasting sepsis-induced immunoparalysis has been principally studied in primary (1)
memory CD8 T cells; however, the impact of sepsis on memory CD8 T cells with a history of …

CJS, MFQ, HT, EG, KL, BJH, DH, and KMQ performed experiments; CJS, VV, MFQ, HT, HYG,
THYD, MPD, DAP, and CMS analyzed data; RAS and DCD provided critical resources; CJS …

Background The capacity of cytomegalovirus (CMV) to elicit long-lasting strong T cell
responses, and the ability to engineer the genome of this DNA virus positions CMV-based …

Human cytomegalovirus (HCMV) induces a uniquely high frequency of virus-specific
effector/memory CD8+ T-cells, a phenomenon termed “memory inflation”. Thus, HCMV …

Human cytomegalovirus (CMV) is a ubiquitous, persistent beta herpesvirus. CMV infection
contributes to the accumulation of functional antigen‐specific CD 8+ T‐cell pools with an …