The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
JL Hsu, MC Hung - Cancer and Metastasis Reviews, 2016 - Springer
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
ALK: a tyrosine kinase target for cancer therapy
VR Holla, YY Elamin, AM Bailey… - Molecular …, 2017 - molecularcasestudies.cshlp.org
The anaplastic lymphoma kinase (ALK) gene plays an important physiologic role in the
development of the brain and can be oncogenically altered in several malignancies …
development of the brain and can be oncogenically altered in several malignancies …
[HTML][HTML] ALK fusions in the pan-cancer setting: another tumor-agnostic target?
A Shreenivas, F Janku, MA Gouda, HZ Chen… - NPJ Precision …, 2023 - nature.com
Anaplastic lymphoma kinase (ALK) alterations (activating mutations, amplifications, and
fusions/rearrangements) occur in~ 3.3% of cancers. ALK fusions/rearrangements are …
fusions/rearrangements) occur in~ 3.3% of cancers. ALK fusions/rearrangements are …
[HTML][HTML] Targeting the ALK–CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex
YY Chu, MK Chen, Y Wei, HH Lee, W Xia, YN Wang… - Nature Cancer, 2022 - nature.com
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated promising
clinical activity in multiple cancers. However, resistance to PARP inhibitors remains a …
clinical activity in multiple cancers. However, resistance to PARP inhibitors remains a …
[HTML][HTML] The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading
Background The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-
silencing pathways It exerts a pivotal role in microRNA maturation and activity and can …
silencing pathways It exerts a pivotal role in microRNA maturation and activity and can …
Telomerase reverse transcriptase mutations are independent predictor of disease‐free survival in M iddle E astern papillary thyroid cancer
R Bu, AK Siraj, SP Divya, Y Kong… - … journal of cancer, 2018 - Wiley Online Library
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Tumor
recurrence occurs in∼ 20% of PTCs and some reach advanced stages. Promoter mutation …
recurrence occurs in∼ 20% of PTCs and some reach advanced stages. Promoter mutation …
[HTML][HTML] A kinome-wide screen using a NanoLuc LATS luminescent biosensor identifies ALK as a novel regulator of the Hippo pathway in tumorigenesis and immune …
The Hippo pathway is an emerging signaling pathway that plays important roles in organ
size control, tissue homeostasis, tumorigenesis, metastasis, drug resistance, and immune …
size control, tissue homeostasis, tumorigenesis, metastasis, drug resistance, and immune …
Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis
R Bu, AK Siraj, KAS Al‐Obaisi, S Beg… - … journal of cancer, 2016 - Wiley Online Library
Ethnic differences of breast cancer genomics have prompted us to investigate the spectra of
BRCA1 and BRCA2 mutations in different populations. The prevalence and effect of BRCA 1 …
BRCA1 and BRCA2 mutations in different populations. The prevalence and effect of BRCA 1 …
[HTML][HTML] XIAP over-expression is an independent poor prognostic marker in Middle Eastern breast cancer and can be targeted to induce efficient apoptosis
AR Hussain, AK Siraj, M Ahmed, R Bu… - BMC cancer, 2017 - Springer
Background Breast cancer is the most common cancer in females and is ranked second in
cancer-related deaths all over the world in women. Despite improvement in diagnosis, the …
cancer-related deaths all over the world in women. Despite improvement in diagnosis, the …
[HTML][HTML] PD-L1 protein expression in middle eastern breast cancer predicts favorable outcome in triple-negative breast cancer
SK Parvathareddy, AK Siraj, SO Ahmed, LO Ghazwani… - Cells, 2021 - mdpi.com
Programmed cell-death ligand 1 (PD-L1) has been shown to induce potent T-cell mediated
anti-tumoral immunity. The significance of PD-L1 expression in the prognosis of breast …
anti-tumoral immunity. The significance of PD-L1 expression in the prognosis of breast …