Self-organization is a process that ensures histogenesis of the eye retina. This highly
intricate phenomenon is not sufficiently studied due to its biological complexity and genetic …

This review covers recent advances in understanding the molecular mechanisms controlling
neurogenesis and specification of the developing retina, with a focus on insights obtained …

Ribosomal proteins are involved in neurodevelopment and central nervous system (CNS)
disease and injury. However, the roles of specific ribosomal protein subunits in …

A central question in development biology is how a limited set of signalling pathways can
instruct unlimited diversity of multicellular organisms. In this review, we use three ocular …

The vertebrate eye is shaped as a cup, a conformation that optimizes vision and is acquired
early in development through a process known as optic cup morphogenesis. Imaging living …

β-Catenin (Ctnnb1) has been shown to play critical roles in the development and
maintenance of epithelial cells, including the retinal pigment epithelium (RPE). Ctnnb1 is not …

In albinism, aberrations in the ipsi-/contralateral retinal ganglion cell (RGC) ratio
compromise the functional integrity of the binocular circuit. Here, we focus on the mouse …

Regeneration of neurons has important implications for human health, and the retina
provides an accessible system to study the potential of replacing neurons following injury. In …

Mutations in the apicobasal polarity gene CRB1 lead to diverse retinal diseases, such as
Leber congenital amaurosis, cone-rod dystrophy, retinitis pigmentosa (with and without …

Sequence variants modulating gene function or expression affect various heritable traits,
including the number of neurons within a population. The present study employed a forward …