Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …

Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate
targeting is facilitated by its co-factor Mtr4p/hMTR4, which links to RNA-binding protein …

Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …

The polyadenosine tail (poly [A]-tail) is a universal modification of eukaryotic messenger
RNAs (mRNAs) and non-coding RNAs (ncRNAs). In budding yeast, Pap1-synthesized …

RNA turnover is an integral part of cellular RNA homeostasis and gene expression
regulation. Whereas the cytoplasmic control of protein-coding mRNA is often the focus of …

Abstract Short Linear Motifs (SLiMs) are the smallest structural and functional components of
modular eukaryotic proteins. They are also the most abundant, especially when considering …

The RNA exosome complex constitutes the major nuclear eukaryotic 3′-5′ exonuclease.
Outside of nucleoli, the human nucleoplasmic exosome is directed to some of its substrates …

The non-coding RNA subunit of telomerase provides the template for telomerase activity. In
diverse fungi, 3′ end processing of telomerase RNA involves a single cleavage by the …