Background: Cancer is spreading all over the world, and it is becoming the leading cause of
major deaths. Today's most difficult task for every researcher is to invent a new drug that can …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that
dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT). This complex binds to …

There is accumulating evidence indicating that aldehyde dehydrogenase (ALDH) activity
selects for cancer cells with increased aggressiveness, capacity for sustained proliferation …

The human cytochrome P450 (CYP) 1A1 gene encodes a monooxygenase that metabolizes
multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its …

Highlights•High ALDH expression in CSCs is associated with a worse prognosis.•ALDH
isozyme expression can to some extent be cancer specific.•Rational approach to chemical …

Despite significant advances in treatment strategies over the past decade, selective
treatment of breast cancer with limited side-effects still remains a great challenge. The …

Currently, clinical intravesical instillation chemotherapy has been greatly compromised by
the toxicological and physiological factors. New formulations that can specifically and …

Over the past decade, there have been significant developments in treatment for ovarian
cancer, yet the lack of targeted therapy with few side effects still represents a major issue …

Background The cytochrome P450 CYP1A1 and CYP1B1 enzymes are involved in
carcinogenesis via activation of pro-carcinogenic compounds to carcinogenic metabolites …

Human cytochrome P450 1A1 (CYP1A1) is an extrahepatic enzyme involved in the
monooxygenation of structurally diverse compounds ranging from natural products to drugs …