The epicardium, the tissue layer covering the cardiac muscle (myocardium), develops from
the proepicardium, a mass of coelomic progenitors located at the venous pole of the …

Cardiogenesis relies on the precise spatiotemporal coordination of multiple progenitor
populations. Understanding the specification and differentiation of these distinct progenitor …

The epicardium is a mesothelial cell layer essential for vertebrate heart development and
pertinent for cardiac repair post-injury in the adult. The epicardium initially forms from a …

The epicardium, a mesothelial layer that envelops vertebrate hearts, has become a
therapeutic target in cardiac repair strategies because of its vital role in heart development …

Rationale: The basic helix–loop–helix (bHLH) transcription factors Hand1 and Hand2 are
essential for embryonic development. Given their requirement for cardiogenesis, it is …

Background/purpose The goal of this study was to determine the role of the collagen binding
receptor integrin α1β1 in regulating osmotically induced [Ca 2+] i transients in chondrocytes …

The heart is a complex organ that is composed of numerous cell types, which must integrate
their programs for proper specification, differentiation and cardiac morphogenesis. During …

The development of the vertebrate embryonic heart occurs by hyperplastic growth as well as
the incorporation of cells from tissues outside of the initial heart field. Amongst these tissues …

During heart development, the epicardium, which originates from the proepicardial organ
(PE), is a source of coronary vessels. The PE develops from the posterior visceral mesoderm …

During heart development, the embryonic ventricle becomes enveloped by the epicardium,
which adheres to the outer apical surface of the heart. This is concomitant with onset of …