Opioids continue to be of use for the treatment of pain. Most clinically used analgesics target
the μ opioid receptor whose activation results in adverse effects like respiratory depression …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Dry leaves of kratom (mitragyna speciosa) are anecdotally consumed as pain relievers and
antidotes against opioid withdrawal and alcohol use disorders. There are at least 54 …

There is significant need to find effective, nonaddictive pain medications. κ Opioid receptor
(KOPr) agonists have been studied for decades but have recently received increased …

Based on the pharmacophore model of opioid receptors, our team recently synthesized a
series of short‐chain hemorphin peptide analogs containing non‐natural amino acids. They …

Effective treatments for chronic pain without abuse liability are urgently needed. One in 5
adults suffer chronic pain and half of these patients report inefficient treatment. Mu opioid …

Substantial evidence from preclinical models of pain suggests that basal and noxious
nociceptive sensitivity, as well as antinociceptive responses to drugs, show significant …

Pain management following acute injury or post‐operative procedures is highly necessary
for proper recovery and quality of life. Opioids and non‐steroidal anti‐inflammatory drugs …

The κ opioid receptor (KOR) is one of the promising targets to develop analgesics lacking
morphine like side effects. To seek a novel KOR agonist we designed 6-amide derivatives …

The present study explored efficient and exclusive analgesic effects of iboga-analogs in
formalin-induced mouse via acute pain model. Novel iboga derivatives namely iboga …