Boveri and beyond: Chromothripsis and genomic instability from mitotic errors
Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …
instability. Failures in accurate chromosome segregation during mitosis can cause …
Chromatin bridges: stochastic breakage or regulated resolution?
H Jiang, YW Chan - Trends in Genetics, 2023 - cell.com
Genetic material is organized in the form of chromosomes, which need to be segregated
accurately into two daughter cells in each cell cycle. However, chromosome fusion or the …
accurately into two daughter cells in each cell cycle. However, chromosome fusion or the …
Extrachromosomal DNA: Biogenesis and Functions in Cancer
In cancer, oncogenes can untether themselves from chromosomes onto circular,
extrachromosomal DNA (ecDNA) particles. ecDNA are common in many of the most …
extrachromosomal DNA (ecDNA) particles. ecDNA are common in many of the most …
[HTML][HTML] Advances in the two-dimensional layer materials for cancer diagnosis and treatment: unique advantages beyond the microsphere
ZW Zhang, Y Yang, H Wu, T Zhang - Frontiers in bioengineering and …, 2023 - frontiersin.org
In recent years, two-dimensional (2D) layer materials have shown great potential in the field
of cancer diagnosis and treatment due to their unique structural, electronic, and chemical …
of cancer diagnosis and treatment due to their unique structural, electronic, and chemical …
[HTML][HTML] Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers
TC Cheong, A Jang, Q Wang, GC Leonardi… - Nature …, 2024 - nature.com
Tyrosine kinase (TK) fusions are frequently found in cancers, either as initiating events or as
a mechanism of resistance to targeted therapy. Partner genes and exons in most TK fusions …
a mechanism of resistance to targeted therapy. Partner genes and exons in most TK fusions …
[HTML][HTML] Disentangling oncogenic amplicons in esophageal adenocarcinoma
Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent
amplifications in oncogenes. However, the mechanisms leading to amplicons that involve …
amplifications in oncogenes. However, the mechanisms leading to amplicons that involve …
[HTML][HTML] Features and applications of Ehrlich tumor model in cancer studies: a literature review
DR Radulski, MC Stipp, CM Galindo… - … Breast Cancer Research, 2023 - ncbi.nlm.nih.gov
Features and applications of Ehrlich tumor model in cancer studies: a literature review - PMC
Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …
Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …
Are we getting closer to a successful neoantigen cancer vaccine?
K Manoutcharian, G Gevorkian - Molecular Aspects of Medicine, 2024 - Elsevier
Although significant advances in immunotherapy have revolutionized the treatment of many
cancer types over the past decade, the field of vaccine therapy, an important component of …
cancer types over the past decade, the field of vaccine therapy, an important component of …
[HTML][HTML] A genetic basis for cancer sex differences revealed in Xp11 translocation renal cell carcinoma
Xp11 translocation renal cell carcinoma (tRCC) is a female-predominant kidney cancer
driven by translocations between the TFE3 gene on chromosome Xp11. 2 and partner …
driven by translocations between the TFE3 gene on chromosome Xp11. 2 and partner …