RNA granules: functional compartments or incidental condensates?
RNA granules are mesoscale assemblies that form in the absence of limiting membranes.
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …
[HTML][HTML] Roles of lncRNAs in brain development and pathogenesis: emerging therapeutic opportunities
T Srinivas, C Mathias, C Oliveira-Mateos, S Guil - Molecular Therapy, 2023 - cell.com
The human genome is pervasively transcribed, producing a majority of short and long
noncoding RNAs (lncRNAs) that can influence cellular programs through a variety of …
noncoding RNAs (lncRNAs) that can influence cellular programs through a variety of …
[HTML][HTML] Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions
Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of
distinct biomolecular condensates that form via phase separation coupled to percolation …
distinct biomolecular condensates that form via phase separation coupled to percolation …
[HTML][HTML] Identification of small molecule inhibitors of G3BP-driven stress granule formation
BD Freibaum, J Messing, H Nakamura… - Journal of Cell …, 2024 - rupress.org
Stress granule formation is triggered by the release of mRNAs from polysomes and is
promoted by the action of the RNA-binding proteins G3BP1/2. Stress granules have been …
promoted by the action of the RNA-binding proteins G3BP1/2. Stress granules have been …
Genome organization around nuclear speckles drives mRNA splicing efficiency
The nucleus is highly organized, such that factors involved in the transcription and
processing of distinct classes of RNA are confined within specific nuclear bodies,. One …
processing of distinct classes of RNA are confined within specific nuclear bodies,. One …
Emerging roles of nuclear bodies in genome spatial organization
Nuclear bodies (NBs) are biomolecular condensates that participate in various cellular
processes and respond to cellular stimuli in the nucleus. The assembly and function of these …
processes and respond to cellular stimuli in the nucleus. The assembly and function of these …
[HTML][HTML] Biomarkers of aging
Aging Biomarker Consortium, H Bao, J Cao… - Science China Life …, 2023 - Springer
Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
Functional domains of nuclear long noncoding RNAs: Insights into gene regulation and intracellular architecture
Recent functional research on long noncoding RNAs (lncRNAs) has revealed their
significant regulatory roles in gene expression and intracellular architecture. Well …
significant regulatory roles in gene expression and intracellular architecture. Well …
Satellite RNAs: emerging players in subnuclear architecture and gene regulation
K Ninomiya, T Yamazaki, T Hirose - The EMBO journal, 2023 - embopress.org
Satellite DNA is characterized by long, tandemly repeated sequences mainly found in
centromeres and pericentromeric chromosomal regions. The recent advent of telomere‐to …
centromeres and pericentromeric chromosomal regions. The recent advent of telomere‐to …
How plants sense and respond to osmotic stress
Drought is one of the most serious abiotic stresses to land plants. Plants sense and respond
to drought stress to survive under water deficiency. Scientists have studied how plants sense …
to drought stress to survive under water deficiency. Scientists have studied how plants sense …