The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …

Channelopathies are a heterogeneous group of disorders resulting from the dysfunction of
ion channels located in the membranes of all cells and many cellular organelles. These …

Potassium (K+) homeostasis is tightly regulated for optimal cell and organismal health.
Failure to control potassium balance results in disease, including cardiac arrythmias and …

Voltage-gated Nav channels are required for normal electrical activity in neurons, skeletal
muscle, and cardiomyocytes. In the heart, Nav1. 5 is the predominant Nav channel, and …

Skeletal muscle ion channelopathies (SMICs) are a large heterogeneous group of rare
genetic disorders caused by mutations in genes encoding ion channel subunits in the …

Andersen–Tawil syndrome (ATS) is a rare hereditary multisystem disorder. Ventricular
arrhythmias, periodic paralysis and dysmorphic features constitute the classic triad of ATS …

The renal outer medullary potassium channel (ROMK) is expressed in the kidney tubule and
critically regulates sodium and potassium balance. The physiological functions of other …

The abrupt cessation of effective cardiac function due to an aberrant heart rhythm can cause
sudden and unexpected death at any age, a syndrome called sudden cardiac death (SCD) …

Abstract Aims Short-QT syndrome (SQTS) is a recently recognized disorder associated with
atrial fibrillation (AF) and sudden death due to ventricular arrhythmias. Mutations in several …