The Ca2+/calmodulin/CaMKK2 axis: nature's metabolic CaMshaft

KL Marcelo, AR Means, B York - Trends in Endocrinology & Metabolism, 2016 - cell.com
Calcium (Ca 2+) is an essential ligand that binds its primary intracellular receptor calmodulin
(CaM) to trigger a variety of downstream processes and pathways. Central to the actions of …

Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review

V Baradaran Rahimi, VR Askari… - Phytotherapy …, 2021 - Wiley Online Library
Metabolic syndrome is known as a group of metabolic abnormalities with features including
central obesity, insulin resistance, hypercholesterolemia, hypertriglyceridemia, and …

Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis

J Dai, K Liang, S Zhao, W Jia, Y Liu… - Proceedings of the …, 2018 - National Acad Sciences
Obesity and related metabolic diseases are becoming worldwide epidemics that lead to
increased death rates and heavy health care costs. Effective treatment options have not …

Current status of herbal medicines in chronic liver disease therapy: the biological effects, molecular targets and future prospects

M Hong, S Li, HY Tan, N Wang, SW Tsao… - International journal of …, 2015 - mdpi.com
Chronic liver dysfunction or injury is a serious health problem worldwide. Chronic liver
disease involves a wide range of liver pathologies that include fatty liver, hepatitis, fibrosis …

Pharmacological properties of baicalin on liver diseases: a narrative review

J Yang, M Li, C Zhang, D Liu - Pharmacological Reports, 2021 - Springer
Baicalin is the main active component of Scutellaria baicalensis, widely used in traditional
Chinese medicine thanks to its various pharmacological effects, such as anti-tumor, anti …

Effects of phytochemicals on macrophage cholesterol efflux capacity: Impact on atherosclerosis

S Soltani, M Boozari, AFG Cicero… - Phytotherapy …, 2021 - Wiley Online Library
High‐density lipoprotein cholesterol (HDL) is the major promoter of reverse cholesterol
transport and efflux of excess cellular cholesterol. The functions of HDL, such as cholesterol …

[HTML][HTML] Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders: A review

R Ganguly, A Gupta, AK Pandey - World journal of …, 2022 - ncbi.nlm.nih.gov
Baicalin is a natural bioactive compound derived from Scutellaria baicalensis, which is
extensively used in traditional Chinese medicine. A literature survey demonstrated the broad …

The pharmacological efficacy of baicalin in inflammatory diseases

Y Wen, Y Wang, C Zhao, B Zhao, J Wang - International Journal of …, 2023 - mdpi.com
Baicalin is one of the most abundant flavonoids found in the dried roots of Scutellaria
baicalensis Georgi (SBG) belonging to the genus Scutellaria. While baicalin is demonstrated …

Regulatory mechanisms of baicalin in cardiovascular diseases: a review

L Xin, J Gao, H Lin, Y Qu, C Shang, Y Wang… - Frontiers in …, 2020 - frontiersin.org
Cardiovascular diseases (CVDs) is the leading cause of high morbidity and mortality
worldwide, which emphasizes the urgent necessity to develop new pharmacotherapies. In …

[HTML][HTML] Baicalin suppresses the progression of Type 2 diabetes-induced liver tumor through regulating METTL3/m6A/HKDC1 axis and downstream p-JAK2/STAT1 …

H Jiang, Q Yao, Y An, L Fan, J Wang, H Li - Phytomedicine, 2022 - Elsevier
Background Epidemiological and clinical evidence suggests that diabetes increases the risk
of liver cancer. Although the co-occurrence of type 2 diabetes (T2D) and liver cancer is …