Obesity and osteoporosis have become major global health problems over the last decades
as their prevalence is increasing. The interaction between obesity and bone metabolism is …

Disruption of bone remodelling by diseases such as osteoporosis results in an imbalance
between bone formation by osteoblasts and resorption by osteoclasts. Research into these …

Purpose: Giant-cell tumor of bone (GCTB) is a locally aggressive, benign osteolytic tumor in
which bone destruction is mediated by RANK ligand (RANKL). The RANKL inhibitor …

Members of the seven-transmembrane receptor (7TMR), or G protein-coupled receptor
(GPCR), superfamily represent some of the most successful targets of modern drug therapy …

Heptahelical G protein-coupled receptors are the most diverse and therapeutically important
family of receptors in the human genome. Ligand binding activates heterotrimeric G proteins …

During the last decades, obesity and osteoporosis have become important global health
problems, and the belief that obesity is protective against osteoporosis has recently come …

Extracellular vesicles (EVs) are newly appreciated regulators of tissue homeostasis and a
means of intercellular communication. Reports have investigated the role of EVs and their …

Bones cannot properly form or be maintained without cell-cell interactions through ephrin
ligands and Eph receptors. Cell culture analysis and evaluation of genetic mouse models …

Periostin (Postn) is a matricellular protein preferentially expressed by osteocytes and
periosteal osteoblasts in response to mechanical stimulation and parathyroid hormone …

Objectives. The present study aimed to investigate the overall effect of quercetin on mouse
bone marrow mesenchymal stem cell (BMSC) proliferation and osteogenic differentiation in …