Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

Gene expression in cells is determined by the epigenetic state of chromatin. Therefore, the
study of epigenetic changes is very important to understand the regulatory mechanism of …

Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Synthetic biology has made significant progress in many areas, but a major challenge that
has received limited attention is the evolutionary stability of synthetic constructs made of …

The preconceptual, intrauterine, and early life environments can have a profound and long-
lasting impact on the developmental trajectories and health outcomes of the offspring. Given …

In this study, we propose iDNA-ABF, a multi-scale deep biological language learning model
that enables the interpretable prediction of DNA methylations based on genomic sequences …

DNA methylation plays crucial roles in many biological processes and abnormal DNA
methylation patterns are often observed in diseases. Recent studies have shed light on cis …

ALUs contribute to genetic diversity by altering DNA's linear sequence through
retrotransposition, recombination and repair. ALUs also have the potential to form alternative …

Abstract Long non‐coding RNAs (LncRNAs) and DNA methylation are important epigenetic
mark play a key role in liver fibrosis. Currently, how DNA methylation and LncRNAs control …