The dramatic global consequences of the coronavirus disease 2019 (COVID-19) pandemic
soon fueled quests for a suitable model that would facilitate the development and testing of …

Substance use disorders (SUDs) are seen as a continuum ranging from goal‐directed and
hedonic drug use to loss of control over drug intake with aversive consequences for mental …

In vitro models of the human blood–brain barrier (BBB) are increasingly used to develop
therapeutics that can cross the BBB for treating diseases of the central nervous system. Here …

The 3Rs principle of replacing, reducing and refining the use of animals in science has been
gaining widespread support in the international research community and appears in …

Findings from animal experiments are often difficult to transfer to humans. In this perspective
article I discuss two questions. First, why are the results of animal experiments often so …

Preregistration of study protocols and, in particular, Registered Reports are novel publishing
formats that are currently gaining substantial traction. Besides rating the research question …

Major achievements in bone research have always relied on animal models and in vitro
systems derived from patient and animal material. However, the use of animals in research …

Various case descriptions and scoring systems have been used to define neonatal calf
diarrhea (NCD) and diverse diarrhea-related outcomes are reported, which limits direct …

The purpose of preclinical research is to inform the development of novel diagnostics or
therapeutics, and the results of experiments on animal models of disease often inform the …

Using animals for research raises ethical concerns that are addressed in project evaluation
by weighing expected harm to animals against expected benefit to society. A harm–benefit …