Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Tetraspanins are a family of proteins with four transmembrane domains that play a role in
many aspects of cell biology and physiology; they are also used by several pathogens for …

Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit
information bidirectionally across the plasma membrane, and plays a critical role in …

Cell-surface proteins of the tetraspanin family are small, and often hidden by a canopy of tall
glycoprotein neighbours in the cell membrane. Consequently, tetraspanins have been …

Venous thromboembolism (VTE), the third leading cause of cardiovascular mortality, is a
complex thrombotic disorder with environmental and genetic determinants. Although several …

The tetraspanin web represents a new concept of molecular interactions in the immune
system. Whereas most surface immune-modulating molecules involve receptor–ligand …

Despite high expression levels at the plasma membrane or in intracellular vesicles,
tetraspanins remain among the most mysterious transmembrane molecules 20 years after …

The tetraspanin transmembrane proteins have emerged as key players in malignancy, the
immune system, during fertilization and infectious disease processes. Tetraspanins engage …

Platelet aggregation is a critical event in thrombus formation and thus has extensive
involvement in physiological and pathological processes. The aggregation response …

Laminins are composed of three polypeptide chains, designated as α, β, and γ. The C-
terminal region of laminin heterotrimers, containing coiled-coil regions, short tails, and …