Norcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD), the main
anticancer active ingredient isolated from traditional Chinese medicine Mylabris. NCTD has …

Lung cancer is the leading cause of cancer death in the world and there is no current
treatment able to efficiently treat the disease as the tumor is often diagnosed at an advanced …

ETHNOPHARMACOLOGICAL RELEVANCE: Following the known principle of “fighting fire
with fire”, poisonous Chinese herbal medicine (PCHM) has been historically used in cancer …

Colorectal cancer (CRC) is a major cause of cancer mortality worldwide, however, the
molecular mechanisms underlying the pathogenesis of CRC remain largely unclear. Recent …

Cancer immunity is regulated by several mechanisms that include co-stimulatory and/or co-
inhibitory molecules known as immune checkpoints expressed by the immune cells. In …

Sp1, the first identified transcription factor, has been reported to be associated with the
development and progression of various human cancer types. However, the clinical …

The roles of aberrantly regulated autophagy in human malignancy and the mechanisms that
initiate and sustain the repression of autophagy in carcinogenesis are less well defined …

Specificity proteins (SPs) and Krüppel-like factors (KLFs) belong to the family of transcription
factors that contain conserved zinc finger domains involved in binding to target DNA …

Many anticancer drugs are obtained from natural sources. Nature produces a variety of toxic
compounds, which are often used as anticancer drugs. Up to now, there are at least 120 …

Background The rate of morbidity and mortality of hepatocellular carcinoma (HCC) in
Taiwan has not lessened because of difficulty in treating tumor metastasis. Norcantharidin …