In silico subtractive genomics for target identification in human bacterial pathogens
Target identification is the first step in the drug and vaccine discovery process; in silico
subtractive genomics is widely used in this process. Using this approach, in recent years, a …
subtractive genomics is widely used in this process. Using this approach, in recent years, a …
Computational approaches to predicting essential proteins: a survey
Essential proteins are indispensable to support cellular life. Identifying essential proteins
can help us understand the minimal requirements for cell survival, which plays a significant …
can help us understand the minimal requirements for cell survival, which plays a significant …
targetTB: A target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis
Background Tuberculosis still remains one of the largest killer infectious diseases,
warranting the identification of newer targets and drugs. Identification and validation of …
warranting the identification of newer targets and drugs. Identification and validation of …
Identification of Putative Vaccine and Drug Targets against the Methicillin-Resistant Staphylococcus aureus by Reverse Vaccinology and Subtractive Genomics …
Methicillin-resistant Staphylococcus aureus (MRSA) is an opportunistic pathogen and
responsible for causing life-threatening infections. The emergence of hypervirulent and …
responsible for causing life-threatening infections. The emergence of hypervirulent and …
[HTML][HTML] Fresh garlic extract enhances the antimicrobial activities of antibiotics on resistant strains in vitro
G Li, X Ma, L Deng, X Zhao, Y Wei, Z Gao… - Jundishapur journal …, 2015 - ncbi.nlm.nih.gov
Background: Infections caused by strains with multi-drug resistance are difficult to treat with
standard antibiotics. Garlic is a powerful remedy to protect against infections of many …
standard antibiotics. Garlic is a powerful remedy to protect against infections of many …
Differential analysis of Orientia tsutsugamushi genomes for therapeutic target identification and possible intervention through natural product inhibitor screening
Z Basharat, U Akhtar, K Khan, G Alotaibi, K Jalal… - Computers in Biology …, 2022 - Elsevier
Orientia tsutsugamushi (Ott) is a causative agent of scrub typhus, and one of the emerging
pathogens that could affect a large human population. It is one of the misdiagnosed and …
pathogens that could affect a large human population. It is one of the misdiagnosed and …
Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genes and Therapeutic Candidates
Mycobacterium ulcerans, the causative agent of Buruli ulcer, is the third most common
mycobacterial disease after tuberculosis and leprosy. The present treatment options are …
mycobacterial disease after tuberculosis and leprosy. The present treatment options are …
Vaccine Development Against Leishmania donovani
A Das, N Ali - Frontiers in immunology, 2012 - frontiersin.org
Visceral leishmaniasis (VL) caused by Leishmania donovani and Leishmania
infantum/chagasi represents the second most challenging infectious disease worldwide …
infantum/chagasi represents the second most challenging infectious disease worldwide …
An In Silico Identification of Common Putative Vaccine Candidates against Treponema pallidum: A Reverse Vaccinology and Subtractive Genomics Based Approach
Sexually transmitted infections (STIs) are caused by a wide variety of bacteria, viruses, and
parasites that are transmitted from one person to another primarily by vaginal, anal, or oral …
parasites that are transmitted from one person to another primarily by vaginal, anal, or oral …
In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae
Neisseria gonorrhoeae is responsible for causing gonorrhea, one of the most common
sexually transmitted diseases prevailing globally. Although extensive researches are in …
sexually transmitted diseases prevailing globally. Although extensive researches are in …