Diabetes is known to cause significant alterations in the retinal vasculature. Indeed, diabetic
retinopathy is the leading cause of blindness in those of working age. Considerable …

Rhodopsin is the first G-protein-coupled receptor (GPCR) with its three-dimensional
structure solved by X-ray crystallography. The crystal structure of rhodopsin has revealed the …

For a long time, there have been no experimentally determined structural data for any
adenosine receptor (AR) and the only approach available for making structure/function …

Bacteriorhodopsin (bR) is a light-driven microbial receptor, and lysine 159 (K159) is a
charged residue on the cytoplasmic (CP) side of its E–F loop. However, its conformation and …

A homology model of the nicotinic acid receptor GPR109A was constructed based on the X-
ray crystal structure of bovine rhodopsin. An HTS hit was docked into the homology model …

Seven transmembrane G protein coupled receptors (7TM GPCRs) represent one of the
largest gene familes in the human genome. Because of the size of the GPCR family, their …

Rhodopsin is the prototypical G‐protein coupled receptor, coupling light activation with high
efficiency to signaling molecules. The dark‐state X‐ray structures of the protein provide a …

Abstract The serotonin 2A (5-HT 2A) receptor is necessary for the psychopharmacological
actions of the serotonergic hallucinogens such as LSD. An exploration of the biophysical …

As crucial members of the G-protein coupled receptor (GPCR) superfamily, α1-adrenergic
receptors (α1-ARs) are recognized to intervene the actions of endogenous catecholamines …

Dietary polyphenols represent a group of secondary metabolites which widely occur in fruits,
vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. Previous …