Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

RP De Vries, R Riley, A Wiebenga, G Aguilar-Osorio… - Genome biology, 2017 - Springer
Abstract Background The fungal genus Aspergillus is of critical importance to humankind.
Species include those with industrial applications, important pathogens of humans, animals …

[HTML][HTML] Endocytosis of nutrient transporters in fungi: The ART of connecting signaling and trafficking

C Barata-Antunes, R Alves, G Talaia, M Casal… - Computational and …, 2021 - Elsevier
Plasma membrane transporters play pivotal roles in the import of nutrients, including sugars,
amino acids, nucleobases, carboxylic acids, and metal ions, that surround fungal cells. The …

Dissection of transporter function: from genetics to structure

G Diallinas - Trends in Genetics, 2016 - cell.com
Transporters are transmembrane proteins mediating the selective uptake or efflux of solutes,
metabolites, drugs, or ions across cellular membranes. Despite their immense biological …

Origin, diversification and substrate specificity in the family of NCS 1/FUR transporters

E Krypotou, T Evangelidis, J Bobonis… - Molecular …, 2015 - Wiley Online Library
NCS 1 proteins are H+/Na+ symporters specific for the uptake of purines, pyrimidines and
related metabolites. In this article, we study the origin, diversification and substrate specificity …

Uracil/H+ Symport by FurE Refines Aspects of the Rocking-bundle Mechanism of APC-type Transporters

I Zantza, Y Pyrris, S Raniolo, GF Papadaki… - Journal of Molecular …, 2023 - Elsevier
Transporters mediate the uptake of solutes, metabolites and drugs across the cell
membrane. The eukaryotic FurE nucleobase/H+ symporter of Aspergillus nidulans has been …

The arrestin‐like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad‐range and specific signals

M Karachaliou, S Amillis, M Evangelinos… - Molecular …, 2013 - Wiley Online Library
We investigated the role of all arrestin‐like proteins of A spergillus nidulans in respect to
growth, morphology, sensitivity to drugs and specifically for the endocytosis and turnover of …

Transport assays in filamentous fungi: kinetic characterization of the UapC purine transporter of Aspergillus nidulans

E Krypotou, G Diallinas - Fungal Genetics and Biology, 2014 - Elsevier
Transport assays allow the direct kinetic analysis of a specific transporter by measuring
apparent K m and V max values, and permit the characterization of substrate specificity …

Modeling, substrate docking, and mutational analysis identify residues essential for the function and specificity of a eukaryotic purine-cytosine NCS1 transporter

E Krypotou, V Kosti, S Amillis… - Journal of Biological …, 2012 - ASBMB
The recent elucidation of crystal structures of a bacterial member of the NCS1 family, the
Mhp1 benzyl-hydantoin permease from Microbacterium liquefaciens, allowed us to construct …

Allantoin transport protein, PucI, from Bacillus subtilis: evolutionary relationships, amplified expression, activity and specificity

P Ma, SG Patching, E Ivanova, JM Baldwin… - …, 2016 - microbiologyresearch.org
This work reports the evolutionary relationships, amplified expression, functional
characterization and purification of the putative allantoin transport protein, PucI, from …

Genome-wide detection of genes under positive selection in worldwide populations of the barley scald pathogen

N Mohd-Assaad, BA McDonald… - Genome biology and …, 2018 - academic.oup.com
Coevolution between hosts and pathogens generates strong selection pressures to maintain
resistance and infectivity, respectively. Genomes of plant pathogens often encode major …