[HTML][HTML] Control of human toxoplasmosis
Toxoplasmosis is caused by Toxoplasma gondii, an apicomplexan parasite that is able to
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …
Gliding motility powers invasion and egress in Apicomplexa
K Frénal, JF Dubremetz, M Lebrun… - Nature Reviews …, 2017 - nature.com
Protozoan parasites have developed elaborate motility systems that facilitate infection and
dissemination. For example, amoebae use actin-rich membrane extensions called …
dissemination. For example, amoebae use actin-rich membrane extensions called …
[HTML][HTML] A genome-wide CRISPR screen in Toxoplasma identifies essential apicomplexan genes
Apicomplexan parasites are leading causes of human and livestock diseases such as
malaria and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we …
malaria and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we …
Drugs in development for toxoplasmosis: advances, challenges, and current status
PH Alday, JS Doggett - Drug design, development and therapy, 2017 - Taylor & Francis
Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are
currently used to treat toxoplasmosis commonly have toxic side effects and require …
currently used to treat toxoplasmosis commonly have toxic side effects and require …
[HTML][HTML] Treatment of toxoplasmosis: Current options and future perspectives
N Konstantinovic, H Guegan, T Stäjner, S Belaz… - Food and waterborne …, 2019 - Elsevier
Toxoplasmosis is a worldwide parasitic disease infecting about one third of humans, with
possible severe outcomes in neonates and immunocompromised patients. Despite …
possible severe outcomes in neonates and immunocompromised patients. Despite …
Lytic Cycle of Toxoplasma gondii: 15 Years Later
IJ Blader, BI Coleman, CT Chen… - Annual review of …, 2015 - annualreviews.org
Toxoplasmosis is the clinical and pathological consequence of acute infection with the
obligate intracellular apicomplexan parasite Toxoplasma gondii. Symptoms result from …
obligate intracellular apicomplexan parasite Toxoplasma gondii. Symptoms result from …
The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling
AC Dar, KM Shokat - Annual review of biochemistry, 2011 - annualreviews.org
Kinases are highly regulated enzymes with diverse mechanisms controlling their catalytic
output. Over time, chemical discovery efforts for kinases have produced ATP-competitive …
output. Over time, chemical discovery efforts for kinases have produced ATP-competitive …
[HTML][HTML] The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries
Plasmodium falciparum and Toxoplasma gondii are obligate intracellular apicomplexan
parasites that rapidly invade and extensively modify host cells. Protein phosphorylation is …
parasites that rapidly invade and extensively modify host cells. Protein phosphorylation is …
A selective review of advances in coccidiosis research
Coccidiosis is a widespread and economically significant disease of livestock caused by
protozoan parasites of the genus Eimeria. This disease is worldwide in occurrence and …
protozoan parasites of the genus Eimeria. This disease is worldwide in occurrence and …
[HTML][HTML] A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1
Mitochondria have long been implicated in the pathogenesis of Parkinson's disease (PD).
Mutations in the mitochondrial kinase PINK1 that reduce kinase activity are associated with …
Mutations in the mitochondrial kinase PINK1 that reduce kinase activity are associated with …