From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

H Han, B Yi, R Zhong, M Wang, S Zhang, J Ma, Y Yin… - Microbiome, 2021 - Springer
Feelings of hunger and satiety are the key determinants for maintaining the life of humans
and animals. Disturbed appetite control may disrupt the metabolic health of the host and …

[HTML][HTML] Functions of gut microbiota metabolites, current status and future perspectives

J Liu, Y Tan, H Cheng, D Zhang, W Feng… - Aging and …, 2022 - ncbi.nlm.nih.gov
Gut microbiota, a collection of microorganisms that live within gastrointestinal tract, provides
crucial signaling metabolites for the physiological of hosts. In healthy state, gut microbiota …

[HTML][HTML] In Alzheimer's disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: randomized, placebo-controlled, double-blind …

M Gejl, A Gjedde, L Egefjord, A Møller… - Frontiers in aging …, 2016 - frontiersin.org
In animal models, the incretin hormone GLP-1 affects Alzheimer's disease (AD). We
hypothesized that treatment with GLP-1 or an analogue of GLP-1 would prevent …

GLP-1 receptor activation modulates appetite-and reward-related brain areas in humans

L van Bloemendaal, RG IJzerman, JS Ten Kulve… - Diabetes, 2014 - Am Diabetes Assoc
Gut-derived hormones, such as GLP-1, have been proposed to relay information to the brain
to regulate appetite. GLP-1 receptor agonists, currently used for the treatment of type 2 …

GLP-1 receptor signaling in astrocytes regulates fatty acid oxidation, mitochondrial integrity, and function

K Timper, A del Río-Martín, AL Cremer, S Bremser… - Cell metabolism, 2020 - cell.com
Astrocytes represent central regulators of brain glucose metabolism and neuronal function.
They have recently been shown to adapt their function in response to alterations in …

Glucagon-like peptide-1 and the central/peripheral nervous system: crosstalk in diabetes

G Muscogiuri, RA DeFronzo, A Gastaldelli… - Trends in Endocrinology …, 2017 - cell.com
Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles
in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation …

Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes

JF Gautier, SP Choukem, J Girard - Diabetes & metabolism, 2008 - Elsevier
Incretin hormones are defined as intestinal hormones released in response to nutrient
ingestion, which potentiate the glucose-induced insulin response. In humans, the incretin …

Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis

AE Hogan, AM Tobin, T Ahern, MA Corrigan… - Diabetologia, 2011 - Springer
Aims/hypothesis The innate immune cells, invariant natural killer T cells (iNKT cells), are
implicated in the pathogenesis of psoriasis, an inflammatory condition associated with …

Brain reward‐system activation in response to anticipation and consumption of palatable food is altered by glucagon‐like peptide‐1 receptor activation in humans

L van Bloemendaal, DJ Veltman… - Diabetes, Obesity …, 2015 - Wiley Online Library
Aim To test the hypothesis that food intake reduction after glucagon‐like peptide‐1 (GLP‐1)
receptor activation is mediated through brain areas regulating anticipatory and …

Pathophysiology linking depression and type 2 diabetes: psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

R Subba, R Sandhir, SP Singh… - European Journal of …, 2021 - Wiley Online Library
Diabetes increases the likelihood of developing depression and vice versa. Research on
this bidirectional association has somewhat managed to delineate the interplay among …