The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Direct neuronal reprogramming is a promising approach to regenerate neurons from local
glial cells. However, mechanisms of epigenome remodeling and co-factors facilitating this …

Ascl1 and Ngn2, closely related proneural transcription factors, are able to convert mouse
embryonic stem cells into induced neurons. Despite their similarities, these factors elicit only …

Cortical neurogenesis follows a simple lineage: apical radial glia cells (RGCs) generate
basal progenitors, and these produce neurons. How this occurs in species with expanded …

Direct neuronal reprogramming is an innovative new technology that involves the
conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent …

Neural progenitor cells in the developing dorsal forebrain generate excitatory neurons
followed by oligodendrocytes (OLs) and astrocytes. However, the specific mechanisms that …

Neurogenins are proneural transcription factors required to specify neuronal identity. Their
overexpression in human pluripotent stem cells rapidly produces cortical-like neurons with …

Direct neuronal reprogramming, the process whereby a terminally differentiated cell is
converted into an induced neuron without traversing a pluripotent state, has tremendous …

Historically, the mammalian brain was thought to lack stem cells as no new neurons were
found to be made in adulthood. That dogma changed∼ 25 years ago with the identification …