The immunological balance between host and parasite in malaria

K Deroost, TT Pham, G Opdenakker… - FEMS microbiology …, 2016 - academic.oup.com
Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

Pathogenetic mechanisms and treatment targets in cerebral malaria

A Hadjilaou, J Brandi, M Riehn, MA Friese… - Nature Reviews …, 2023 - nature.com
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

Lipid hijacking: a unifying theme in vector-borne diseases

AJ O'Neal, LR Butler, A Rolandelli, SD Gilk, JHF Pedra - Elife, 2020 - elifesciences.org
Vector-borne illnesses comprise a significant portion of human maladies, representing 17%
of global infections. Transmission of vector-borne pathogens to mammals primarily occurs …

The malaria parasite has an intrinsic clock

F Rijo-Ferreira, VA Acosta-Rodriguez, JH Abel… - Science, 2020 - science.org
Malarial rhythmic fevers are the consequence of the synchronous bursting of red blood cells
(RBCs) on completion of the malaria parasite asexual cell cycle. Here, we hypothesized that …

Cerebral malaria: current clinical and immunological aspects

K Albrecht-Schgoer, P Lackner… - Frontiers in …, 2022 - frontiersin.org
This review focuses on current clinical and immunological aspects of cerebral malaria
induced by Plasmodium falciparum infection. Albeit many issues concerning the …

Tissue tropism in parasitic diseases

S Silva Pereira, S Trindade, M De Niz… - Open …, 2019 - royalsocietypublishing.org
Parasitic diseases, such as sleeping sickness, Chagas disease and malaria, remain a major
cause of morbidity and mortality worldwide, but particularly in tropical, developing countries …

Tissue-specific immunopathology during malaria infection

C Coban, MSJ Lee, KJ Ishii - Nature Reviews Immunology, 2018 - nature.com
Systemic inflammation mediated by Plasmodium parasites is central to malaria disease and
its complications. Plasmodium parasites reside in erythrocytes and can theoretically reach …

Pathogenesis of malaria-associated acute respiratory distress syndrome

PE Van den Steen, K Deroost, J Deckers… - Trends in …, 2013 - cell.com
Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an increasingly
reported, often lethal, and incompletely understood complication of malaria. We discuss and …

[HTML][HTML] Comparative spatial proteomics of Plasmodium-infected erythrocytes

A Siau, JW Ang, O Sheriff, R Hoo, HP Loh, D Tay… - Cell Reports, 2023 - cell.com
Plasmodium parasites contribute to one of the highest global infectious disease burdens. To
achieve this success, the parasite has evolved a range of specialized subcellular …

The Plasmodium translocon of exported proteins (PTEX) component thioredoxin‐2 is important for maintaining normal blood‐stage growth

K Matthews, M Kalanon, SA Chisholm… - Molecular …, 2013 - Wiley Online Library
P lasmodium parasites remodel their vertebrate host cells by translocating hundreds of
proteins across an encasing membrane into the host cell cytosol via a putative export …