Opioids produce strong analgesia but their use is limited by a paradoxical hypersensitivity
named opioid-induced hyperalgesia (OIH) that may be associated to analgesic tolerance. In …

Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …

As early as the 19th century, OIH was observed in patients receiving morphine for pain. It
was recognized that a potent analgesic such as morphine could actually result in an …

Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

primate research suggests that affiliation is a highly complex construct. studies of primate
affiliation demonstrate the need to distinguish between various affiliative behaviors, consider …

Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although
common concerns regarding the use of opioids include the potential for detrimental side …

A difficult decision for physicians who treat patients with chronic pain not associated with
terminal disease is whether and how to prescribe opioid therapy, which can relieve pain and …

Opioid-induced hyperalgesia (OIH) is most broadly defined as a state of nociceptive
sensitization caused by exposure to opioids. The state is characterized by a paradoxical …

Objective To discuss the phenomenon of opioid induced hyperalgesia (OIH) and investigate
the data and clinical recommendations available on this topic. Design A literature search on …

Over the last several years, compelling evidence has accumulated indicating that central
hyperactive states resulting from neuronal plastic changes within the spinal cord play a …