The recent advancement in spatial transcriptomics technology has enabled multiplexed
profiling of cellular transcriptomes and spatial locations. As the capacity and efficiency of the …

We used the 10x Genomics Visium platform to define the spatial topography of gene
expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive …

Objective To evaluate the application of RNAscope in the clinical diagnostic field compared
to the current 'gold standard'methods employed for testing gene expression levels, including …

Single-cell gene expression technologies are powerful tools to study cell types in the human
brain, but efforts have largely focused on cortical brain regions. We therefore created a …

Sex hormones exert a profound influence on gendered behaviors. How individual sex
hormone-responsive neuronal populations regulate diverse sex-typical behaviors is unclear …

Background Schizophrenia is a severe mental illness afflicting young adults just as they
approach their full potential, often resulting in a lifetime of severe disability. While many …

We define and identify a new class of control genes for next-generation sequencing called
total RNA expression genes (TREGs), which correlate with total RNA abundance in cell …

The molecular organization of the human neocortex historically has been studied in the
context of its histological layers. However, emerging spatial transcriptomic technologies …

Objective: Posttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric disease
that is highly comorbid with major depressive disorder (MDD) and bipolar disorder. The …

Alveolar epithelial cell fate decisions drive lung development and regeneration. Using
transcriptomic and epigenetic profiling coupled with genetic mouse and organoid models …