Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD)
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …

The format of the original Hamilton Rating Scale for Depression (HAM-D) was unstructured:
only general instructions were provided for rating individual items. Over the years, a number …

Objective: About one-third of patients with depression fail to achieve remission despite
treatment with multiple antidepressants. This study compared the efficacy and safety of …

Importance Controlled studies have shown short-term efficacy of esketamine for treatment-
resistant depression (TRD), but long-term effects remain to be established. Objective To …

Background About one-third of patients with depression fail to achieve remission despite
treatment with multiple antidepressants and are considered to have treatment-resistant …

Importance Approximately one-third of patients with major depressive disorder (MDD) do not
respond to available antidepressants. Objective To assess the efficacy, safety, and dose …

Background Elderly patients with major depression have a poorer prognosis, are less
responsive to treatment, and show greater functional decline compared with younger …

Context Increased concentrations of inflammatory biomarkers predict antidepressant
nonresponse, and inflammatory cytokines can sabotage and circumvent the mechanisms of …

Background: The best treatment options for binge-eating disorder are unclear. Purpose: To
summarize evidence about the benefits and harms of psychological and pharmacologic …

Background The purpose of this study was to assess the efficacy and safety and to explore
the dose response of esketamine intravenous (IV) infusion in patients with treatment …