Gap junctions and cancer: communicating for 50 years
Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …
that loss of direct intercellular communication is commonly associated with cancer onset and …
Gap junctions in liver disease: Implications for pathogenesis and therapy
In the normal liver, cells interact closely through gap junctions. By providing a pathway for
the trafficking of low molecular mass molecules, these channels contribute to tissue …
the trafficking of low molecular mass molecules, these channels contribute to tissue …
[HTML][HTML] Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer
C Georgikou, L Yin, J Gladkich, X Xiao, C Sticht… - Cancer Letters, 2020 - Elsevier
The therapy resistance of pancreatic cancer is associated with the loss of gap junction
intercellular communication and connexin 43 expression. The broccoli isothiocyanate …
intercellular communication and connexin 43 expression. The broccoli isothiocyanate …
Targeting connexin 43 with α–connexin carboxyl-terminal (ACT1) peptide enhances the activity of the targeted inhibitors, tamoxifen and lapatinib, in breast cancer …
CL Grek, JM Rhett, JS Bruce, MA Abt, GS Ghatnekar… - BMC cancer, 2015 - Springer
Background Treatment failure is a critical issue in breast cancer and identifying useful
interventions that optimize current cancer therapies remains a critical unmet need …
interventions that optimize current cancer therapies remains a critical unmet need …
Connexin 43, breast cancer tumor suppressor: Missed connections?
CL Grek, JM Rhett, JS Bruce, GS Ghatnekar, ES Yeh - Cancer letters, 2016 - Elsevier
Connexins are a family of transmembrane proteins that are characterized by their capacity to
form intercellular channels called gap junctions that directly link the cytoplasm of adjacent …
form intercellular channels called gap junctions that directly link the cytoplasm of adjacent …
Gap junction intercellular communication positively regulates cisplatin toxicity by inducing DNA damage through bystander signaling
The radiation-induced bystander effect (RIBE) can increase cellular toxicity in a gap junction
dependent manner in unirradiated bystander cells. Recent reports have suggested that …
dependent manner in unirradiated bystander cells. Recent reports have suggested that …
The role of gap junctions in inflammatory and neoplastic disorders
P Wong, V Laxton, S Srivastava… - International …, 2017 - spandidos-publications.com
Gap junctions are intercellular channels made of connexin proteins, mediating both
electrical and biochemical signals between cells. The ability of gap junction proteins to …
electrical and biochemical signals between cells. The ability of gap junction proteins to …
Ion channel and neurotransmitter modulators as electroceutical approaches to the control of cancer
The activities of individual cells must be tightly coordinated in order to build and maintain
complex 3-dimensional body structures during embryogenesis and regeneration. Thus, one …
complex 3-dimensional body structures during embryogenesis and regeneration. Thus, one …
Non-coding RNA as mediators in microenvironment–breast cancer cell communication
The tumor microenvironment has a critical role in the survival and decision of the cancer
cells. These include support by enhanced angiogenesis, and metastasis or adaptation of …
cells. These include support by enhanced angiogenesis, and metastasis or adaptation of …
Connexin-containing vesicles for drug delivery
MS Hanafy, Z Cui - The AAPS Journal, 2024 - Springer
Connexin is a transmembrane protein present on the cell membrane of most cell types.
Connexins assemble into a hexameric hemichannel known as connexon that pairs with …
Connexins assemble into a hexameric hemichannel known as connexon that pairs with …