Static and dynamic: evolving biomaterial mechanical properties to control cellular mechanotransduction

W Xie, X Wei, H Kang, H Jiang, Z Chu, Y Lin… - Advanced …, 2023 - Wiley Online Library
The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …

Regulation of stem cell fate using nanostructure-mediated physical signals

Y Kong, J Duan, F Liu, L Han, G Li, C Sun… - Chemical Society …, 2021 - pubs.rsc.org
One of the major issues in tissue engineering is regulation of stem cell differentiation toward
specific lineages. Unlike biological and chemical signals, physical signals with adjustable …

Bioinspired mild photothermal effect-reinforced multifunctional fiber scaffolds promote bone regeneration

X Zhang, Q Li, L Li, J Ouyang, T Wang, J Chen, X Hu… - ACS …, 2023 - ACS Publications
Bone fractures are often companied with poor bone healing and high rates of infection. Early
recruitment of mesenchymal stem cells (MSCs) is critical for initiating efficient bone repair …

Highly Effective and Noninvasive Near‐Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min

M Li, L Li, K Su, X Liu, T Zhang, Y Liang… - Advanced …, 2019 - Wiley Online Library
Biofilms have been related to the persistence of infections on medical implants, and these
cannot be eradicated because of the resistance of biofilm structures. Therefore, a …

Programmable integrin and N-cadherin adhesive interactions modulate mechanosensing of mesenchymal stem cells by cofilin phosphorylation

Z Zhang, B Sha, L Zhao, H Zhang, J Feng… - Nature …, 2022 - nature.com
During mesenchymal development, the sources of mechanical forces transduced by cells
transition over time from predominantly cell-cell interactions to predominantly cell …

Biomimetic micro/nano structures for biomedical applications

T Xiang, J Hou, H Xie, X Liu, T Gong, S Zhou - Nano Today, 2020 - Elsevier
Cell behaviors are influenced by the surrounding dynamic microenvironment where the
extracellular matrix (ECM) composed of different micro/nano-structures plays a key role …

Manipulating cell fate: dynamic control of cell behaviors on functional platforms

W Li, Z Yan, J Ren, X Qu - Chemical Society Reviews, 2018 - pubs.rsc.org
The cell microenvironment choreographs the behaviors of cells through multiple well-
controlled signals. For basic biological study and cell-based therapies, it is essential to …

Manipulating nanoparticle aggregates regulates receptor–ligand binding in macrophages

Y Kim, HJ Jung, Y Lee, S Koo, R Thangam… - Journal of the …, 2022 - ACS Publications
The receptor–ligand interactions in cells are dynamically regulated by modulation of the
ligand accessibility. In this study, we utilize size-tunable magnetic nanoparticle aggregates …

Modulation of macrophages by in situ ligand bridging

SY Kim, R Thangam, N Kang, H Hong… - Advanced Functional …, 2023 - Wiley Online Library
Extracellular matrix (ECM) proteins containing cell‐attachable Arg‐Gly‐Asp (RGD)
sequences exhibit variable bridging and non‐bridging in fibronectin‐collagen and laminin …

Arrowhead composite microneedle patches with anisotropic surface adhesion for preventing intrauterine adhesions

X Zhang, G Chen, Y Wang, L Fan, Y Zhao - Advanced Science, 2022 - Wiley Online Library
Biomedical patches are considered as a promising strategy to help tissue repair and
regeneration, prevent tissue adhesion, and reduce neighboring friction. Here, novel …