Recent trends in pharmaceutical analysis to foster modern drug discovery by comparative in-silico profiling of drugs and related substances
SB Ganorkar, Y Vander Heyden - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Pharmaceutical drug analysis (PDA), besides quantifying drugs and related substances
(RS), can enrich drug discovery (DD) by suggesting new leads. PDA may be extended …
(RS), can enrich drug discovery (DD) by suggesting new leads. PDA may be extended …
Choices of chromatographic methods as stability indicating assays for pharmaceutical products: A review
YL Chew, MA Khor, YY Lim - Heliyon, 2021 - cell.com
Stability indicating assay describes a technique which is used to analyse the stability of drug
substance or active pharmaceutical ingredient (API) in bulk drug and pharmaceutical …
substance or active pharmaceutical ingredient (API) in bulk drug and pharmaceutical …
[HTML][HTML] Implementation of green analytical principles to develop and validate the HPLC method for the separation and identification of degradation products of …
Panobinostat (PAN) is an inhibitor of histone deacetylase (HDAC) that has been granted
approval by the US Regulator for the purpose of treating chronic lymphocytic leukemia …
approval by the US Regulator for the purpose of treating chronic lymphocytic leukemia …
Characterization of stress degradation products of nintedanib by UPLC, UHPLC-Q-TOF/MS/MS and NMR: Evidence of a degradation product with a structure alert for …
Nintedanib is an anti-cancer drug used for the treatment of idiopathic pulmonary fibrosis and
non-small cell lung cancer. The purpose of this study was to explore its degradation …
non-small cell lung cancer. The purpose of this study was to explore its degradation …
Targeted Isolation of Cytotoxic Sesquiterpene Lactones from Eupatorium fortunei by the NMR Annotation Tool, SMART 2.0
J Lee, J Park, J Kim, B Jeong, SY Choi, HS Jang… - ACS …, 2020 - ACS Publications
Small Molecular Accurate Recognition Technology (SMART 2.0) has recently been
introduced as a NMR-based machine learning tool for the discovery and characterization of …
introduced as a NMR-based machine learning tool for the discovery and characterization of …
Can NMR spectroscopy discriminate between NPS amphetamines and cathinones? An evaluation by in silico studies and chemometrics
The use of new psychoactive substances (NPS) has become a problem that affects many
countries. Because new chemical structures appear frequently and reliable reference data …
countries. Because new chemical structures appear frequently and reliable reference data …
Characterization of photodegradation products of bepotastine besilate and in silico evaluation of their physicochemical, absorption, distribution, metabolism, excretion …
Bepotastine (BPT) is a H 1-receptor antagonist. It is used as a besilate salt in ophthalmic
solution for allergic conjunctivitis and orally for the treatment of allergic rhinitis and …
solution for allergic conjunctivitis and orally for the treatment of allergic rhinitis and …
Isolation, characterization, and toxicity study of stress degradation products of Pranlukast Hydrate
KJ Prajapati, CS Kothari - Chemical Research in Toxicology, 2022 - ACS Publications
Pranlukast hydrate (PRN), a cysteinyl leukotriene receptor antagonist (CysLT1), is used to
treat bronchial asthma. The objective of this study is to perform the isolation …
treat bronchial asthma. The objective of this study is to perform the isolation …
Insights into the degradation chemistry of tazarotene, a third generation acetylenic retinoid: LC-HRMS (Orbitrap), LC-MSn and NMR characterization of its degradation …
Tazarotene is a prodrug that belongs to the acetylenic class of retinoids. The drug was
subjected to hydrolytic, oxidative and photolytic stress testing to establish its comprehensive …
subjected to hydrolytic, oxidative and photolytic stress testing to establish its comprehensive …
Stability behaviour of antiretroviral drugs and their combinations. 11: Characterization of interaction products of zidovudine and efavirenz, and evaluation of their anti …
Zidovudine (ZDV) and efavirenz (EFV), which belong to two separate classes of antiretroviral
drugs, viz., NRTI and NNRTI, respectively, were subjected to different stability test conditions …
drugs, viz., NRTI and NNRTI, respectively, were subjected to different stability test conditions …