The maternal-to-zygotic transition revisited
The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …
Enhancer DNA methylation: implications for gene regulation
A Angeloni, O Bogdanovic - Essays in biochemistry, 2019 - portlandpress.com
DNA methylation involves the addition of a methyl group to the fifth carbon of the pyrimidine
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …
A high-resolution mRNA expression time course of embryonic development in zebrafish
We have produced an mRNA expression time course of zebrafish development across 18
time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos …
time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos …
A map of cis-regulatory elements and 3D genome structures in zebrafish
The zebrafish (Danio rerio) has been widely used in the study of human disease and
development, and about 70% of the protein-coding genes are conserved between the two …
development, and about 70% of the protein-coding genes are conserved between the two …
The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo
G Crispatzu, R Rehimi, T Pachano, T Bleckwehl… - Nature …, 2021 - nature.com
Poised enhancers (PEs) represent a genetically distinct set of distal regulatory elements that
control the expression of major developmental genes. Before becoming activated in …
control the expression of major developmental genes. Before becoming activated in …
Epigenetics in teleost fish: From molecular mechanisms to physiological phenotypes
While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …
phenotypes in mammalian research models across different developmental and …
Systemic loss and gain of chromatin architecture throughout zebrafish development
The spatial organization of chromosomes is critical in establishing gene expression
programs. We generated in situ Hi-C maps throughout zebrafish development to gain insight …
programs. We generated in situ Hi-C maps throughout zebrafish development to gain insight …
Identification and functional characterization of cardiac pacemaker cells in zebrafish
F Tessadori, JH van Weerd, SB Burkhard, AO Verkerk… - 2012 - journals.plos.org
In the mammalian heart a conduction system of nodes and conducting cells generates and
transduces the electrical signals evoking myocardial contractions. Specialized pacemaker …
transduces the electrical signals evoking myocardial contractions. Specialized pacemaker …
Chromatin accessibility is associated with CRISPR-Cas9 efficiency in the zebrafish (Danio rerio)
MIE Uusi-Mäkelä, HR Barker, CA Bäuerlein… - PloS one, 2018 - journals.plos.org
CRISPR-Cas9 technology is routinely applied for targeted mutagenesis in model organisms
and cell lines. Recent studies indicate that the prokaryotic CRISPR-Cas9 system is affected …
and cell lines. Recent studies indicate that the prokaryotic CRISPR-Cas9 system is affected …
Chromatin accessibility established by Pou5f3, Sox19b and Nanog primes genes for activity during zebrafish genome activation
In many organisms, early embryonic development is driven by maternally provided factors
until the controlled onset of transcription during zygotic genome activation. The regulation of …
until the controlled onset of transcription during zygotic genome activation. The regulation of …