The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease
Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
M Morikawa, R Derynck… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and
differentiation factors, which is encoded by 33 genes in mammals and comprises homo-and …
differentiation factors, which is encoded by 33 genes in mammals and comprises homo-and …
2022 ACC/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association/American College of Cardiology Joint …
Writing Committee Members, EM Isselbacher… - Journal of the American …, 2022 - jacc.org
Abstract Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …
Arrhythmogenic cardiomyopathy
D Corrado, C Basso, DP Judge - Circulation research, 2017 - Am Heart Assoc
Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder, predisposing to
sudden cardiac death, particularly in young patients and athletes. Pathological features …
sudden cardiac death, particularly in young patients and athletes. Pathological features …
Aortic aneurysms: current pathogenesis and therapeutic targets
MJ Cho, MR Lee, JG Park - Experimental & Molecular Medicine, 2023 - nature.com
Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta,
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …
[HTML][HTML] Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome
JAN Meester, A Verstraeten, D Schepers… - Annals of …, 2017 - ncbi.nlm.nih.gov
Many different heritable connective tissue disorders (HCTD) have been described over the
past decades. These syndromes often affect the connective tissue of various organ systems …
past decades. These syndromes often affect the connective tissue of various organ systems …
Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape
CJ Martin, A Datta, C Littlefield, A Kalra… - Science translational …, 2020 - science.org
Despite breakthroughs achieved with cancer checkpoint blockade therapy (CBT), many
patients do not respond to anti–programmed cell death-1 (PD-1) due to primary or acquired …
patients do not respond to anti–programmed cell death-1 (PD-1) due to primary or acquired …
TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis
T Sun, Z Huang, WC Liang, J Yin, WY Lin… - Science translational …, 2021 - science.org
Transforming growth factor–β (TGFβ) is a key driver of fibrogenesis. Three TGFβ isoforms
(TGFβ1, TGFβ2, and TGFβ3) in mammals have distinct functions in embryonic development; …
(TGFβ1, TGFβ2, and TGFβ3) in mammals have distinct functions in embryonic development; …
Hereditary influence in thoracic aortic aneurysm and dissection
Thoracic aortic aneurysm is a potentially life-threatening condition in that it places patients at
risk for aortic dissection or rupture. However, our modern understanding of the pathogenesis …
risk for aortic dissection or rupture. However, our modern understanding of the pathogenesis …
Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm
Loeys-Dietz syndrome (LDS) associates with a tissue signature for high transforming growth
factor (TGF)-β signaling but is often caused by heterozygous mutations in genes encoding …
factor (TGF)-β signaling but is often caused by heterozygous mutations in genes encoding …