Electrochemical methods for the analysis of clinically relevant biomolecules

M Labib, EH Sargent, SO Kelley - Chemical reviews, 2016 - ACS Publications
Rapid progress in identifying biomarkers that are hallmarks of disease has increased
demand for high-performance detection technologies. Implementation of electrochemical …

[HTML][HTML] A review on macroscale and microscale cell lysis methods

M Shehadul Islam, A Aryasomayajula… - Micromachines, 2017 - mdpi.com
The lysis of cells in order to extract the nucleic acids or proteins inside it is a crucial unit
operation in biomolecular analysis. This paper presents a critical evaluation of the various …

Electrochemistry, biosensors and microfluidics: a convergence of fields

DG Rackus, MH Shamsi, AR Wheeler - Chemical Society Reviews, 2015 - pubs.rsc.org
Electrochemistry, biosensors and microfluidics are popular research topics that have
attracted widespread attention from chemists, biologists, physicists, and engineers. Here, we …

An electrochemical clamp assay for direct, rapid analysis of circulating nucleic acids in serum

J Das, I Ivanov, L Montermini, J Rak, EH Sargent… - Nature …, 2015 - nature.com
The analysis of cell-free nucleic acids (cfNAs), which are present at significant levels in the
blood of cancer patients, can reveal the mutational spectrum of a tumour without the need for …

DNA clutch probes for circulating tumor DNA analysis

J Das, I Ivanov, EH Sargent… - Journal of the American …, 2016 - ACS Publications
Progress toward the development of minimally invasive liquid biopsies of disease is being
bolstered by breakthroughs in the analysis of circulating tumor DNA (ctDNA): DNA released …

[HTML][HTML] A review on potential electrochemical point-of-care tests targeting pandemic infectious disease detection: COVID-19 as a reference

GC Biswas, S Choudhury, MM Rabbani, J Das - Chemosensors, 2022 - mdpi.com
Fast and accurate point-of-care testing (POCT) of infectious diseases is crucial for
diminishing the pandemic miseries. To fight the pandemic coronavirus disease 2019 …

Emerging microtechnologies and automated systems for rapid bacterial identification and antibiotic susceptibility testing

Y Li, X Yang, W Zhao - SLAS TECHNOLOGY: Translating …, 2017 - journals.sagepub.com
Rapid bacterial identification (ID) and antibiotic susceptibility testing (AST) are in great
demand due to the rise of drug-resistant bacteria. Conventional culture-based AST methods …

Chemistry-driven approaches for ultrasensitive nucleic acid detection

SJ Smith, CR Nemr, SO Kelley - Journal of the American Chemical …, 2017 - ACS Publications
Methods that can rapidly and specifically analyze nucleic acid sequences will revolutionize
the diagnosis and treatment of disease by allowing molecular-level information to be used …

Nanoparticle-Mediated Capture and Electrochemical Detection of Methicillin-Resistant Staphylococcus aureus

CR Nemr, SJ Smith, W Liu, AH Mepham… - Analytical …, 2019 - ACS Publications
The spread of antibiotic-resistant bacteria poses a global threat to public health.
Conventional bacterial detection and identification methods often require pre-enrichment …

Ultrasensitive electrochemical biomolecular detection using nanostructured microelectrodes

AT Sage, JD Besant, B Lam, EH Sargent… - Accounts of chemical …, 2014 - ACS Publications
Conspectus Electrochemical sensors have the potential to achieve sensitive, specific, and
low-cost detection of biomolecules a capability that is ever more relevant to the diagnosis …