A Model of iPSC-Derived Macrophages with TNFAIP3 Overexpression Reveals the Peculiarities of TNFAIP3 Protein Expression and Function in Human …

O Sheveleva, E Protasova, T Nenasheva… - International Journal of …, 2023 - mdpi.com
Macrophages play a crucial role in the development and control of inflammation.
Understanding the mechanisms balancing macrophage inflammatory activity is important to …

Visualizing hydrogen peroxide and nitric oxide dynamics in endothelial cells using multispectral imaging under controlled oxygen conditions

HY Altun, M Secilmis, F Yang, TA Caglar… - Free Radical Biology …, 2024 - Elsevier
The complex interplay between hydrogen peroxide (H 2 O 2) and nitric oxide (NO) in
endothelial cells presents challenges due to technical limitations in simultaneous …

Hydrogen peroxide is not generated intracellularly in human neural spheroids during ischemia-reperfusion

VS Usatova, NM Mishina, MA Berestovoy… - Free Radical Biology …, 2024 - Elsevier
Reactive oxygen species (ROS) are considered a primary source of damage during
ischemic stroke. However, the precise timing of ROS production (during hypoxia or …

Generation of iPSCs from a Patient with the M694V Mutation in the MEFV Gene Associated with Familial Mediterranean Fever and Their Differentiation into …

EV Grigor'eva, LV Karapetyan, AA Malakhova… - International Journal of …, 2024 - mdpi.com
Familial Mediterranean fever (FMF) is a systemic autoinflammatory disorder caused by
inherited mutations in the MEFV (Mediterranean FeVer) gene, located on chromosome 16 …

Detection of ER Stress in iPSC-Derived Neurons Carrying the p.N370S Mutation in the GBA1 Gene

ES Yarkova, EV Grigor'eva, SP Medvedev… - Biomedicines, 2024 - mdpi.com
Endoplasmic reticulum (ER) stress is involved in the pathogenesis of many human diseases,
such as cancer, type 2 diabetes, kidney disease, atherosclerosis and neurodegenerative …

The myokine FGF21 associates with enhanced survival in ALS and mitigates stress-induced cytotoxicity

A Guha, Y Si, R Smith, M Kazamel, N Jiang, KA Smith… - bioRxiv, 2024 - biorxiv.org
Amyotrophic lateral sclerosis (ALS) is an age-related and fatal neurodegenerative disease
characterized by progressive muscle weakness. There is marked heterogeneity in clinical …

Effect of M694V mutation in the MEFV gene, associated with Familial Mediterranean fever, on the morphology of iPSC-derived macrophages

EV Grigor'eva, LV Karapetyan, AA Malakhova… - 2024 - preprints.org
Familial Mediterranean fever (FMF) is a systemic autoinflammatory disorder caused by
inherited mutations in the MEFV (Mediterranean FeVer) gene located on chromosome 16 …