Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection

F Caiado, EM Pietras, MG Manz - Journal of Experimental Medicine, 2021 - rupress.org
Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Cytokines and radiation-induced pulmonary injuries

A Lierova, M Jelicova, M Nemcova… - Journal of radiation …, 2018 - academic.oup.com
Radiation therapy is one of the most common treatment strategies for thorax malignancies.
One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is …

COVID‐19: Proposing a Ketone‐Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm

PC Bradshaw, WA Seeds, AC Miller… - Oxidative Medicine …, 2020 - Wiley Online Library
Human SARS‐CoV‐2 infection is characterized by a high mortality rate due to some patients
developing a large innate immune response associated with a cytokine storm and acute …

[HTML][HTML] A pattern of early radiation-induced inflammatory cytokine expression is associated with lung toxicity in patients with non-small cell lung cancer

S Siva, M MacManus, T Kron, N Best, J Smith… - PloS one, 2014 - journals.plos.org
Purpose Lung inflammation leading to pulmonary toxicity after radiotherapy (RT) can occur
in patients with non-small cell lung cancer (NSCLC). We investigated the kinetics of RT …

Lung parenchyma-derived IL-6 promotes IL-17A–dependent acute lung injury after allogeneic stem cell transplantation

A Varelias, KH Gartlan, E Kreijveld… - Blood, The Journal …, 2015 - ashpublications.org
Idiopathic pneumonia syndrome (IPS) is a relatively common, frequently fatal clinical entity,
characterized by noninfectious acute lung inflammation following allogeneic stem cell …

[HTML][HTML] The role of myeloid-derived suppressor cells (MDSCs) in graft-versus-host disease (GVHD)

C Demosthenous, I Sakellari, V Douka… - Journal of clinical …, 2021 - mdpi.com
Background: Myeloid-derived suppressor cells (MDSCs) are implicated in the complex
interplay involving graft-versus-leukemia (GVL) effects and graft-versus-host disease …

[HTML][HTML] Circulating interleukin-18 as a biomarker of total-body radiation exposure in mice, minipigs, and nonhuman primates (NHP)

CT Ha, XH Li, D Fu, M Moroni, C Fisher, R Arnott… - PloS one, 2014 - journals.plos.org
We aim to develop a rapid, easy-to-use, inexpensive and accurate radiation dose-
assessment assay that tests easily obtained samples (eg, blood) to triage and track …

Immunological markers that predict radiation toxicity

CN Sprung, HB Forrester, S Siva, OA Martin - Cancer letters, 2015 - Elsevier
Radiotherapy is a major modality of cancer treatment responsible for a large proportion of
cancer that is cured. Radiation exposure induces an inflammatory response which can be …

[HTML][HTML] The NIAID/RNCP biodosimetry program: An overview

MM Satyamitra, DR Cassatt, O Molinar-Inglis… - … and Genome Research, 2023 - karger.com
Established in 2004, the Radiation and Nuclear Countermeasures Program (RNCP), within
the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health …

[HTML][HTML] Delta-tocotrienol suppresses radiation-induced microRNA-30 and protects mice and human CD34+ cells from radiation injury

XH Li, CT Ha, D Fu, MR Landauer, SP Ghosh, M Xiao - PLoS One, 2015 - journals.plos.org
We reported that microRNA-30c (miR-30c) plays a key role in radiation-induced human cell
damage through an apoptotic pathway. Herein we further evaluated radiation-induced miR …