Understanding the pathogenesis of spondyloarthritis
A Sharip, J Kunz - Biomolecules, 2020 - mdpi.com
Spondyloarthritis comprises a group of inflammatory diseases of the joints and spine, with
various clinical manifestations. The group includes ankylosing spondylitis, reactive arthritis …
various clinical manifestations. The group includes ankylosing spondylitis, reactive arthritis …
Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2)
A Raja, JJW Kuiper - Genes & Immunity, 2023 - nature.com
Abstract Endoplasmic reticulum aminopeptidase 2 (ERAP2) is a proteolytic enzyme involved
in adaptive immunity. The ERAP2 gene is highly polymorphic and encodes haplotypes that …
in adaptive immunity. The ERAP2 gene is highly polymorphic and encodes haplotypes that …
Discovery of biomarkers for amyotrophic lateral sclerosis from human cerebrospinal fluid using mass-spectrometry-based proteomics
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by the loss of upper and lower motor neurons, which eventually may lead to …
characterized by the loss of upper and lower motor neurons, which eventually may lead to …
The impact of the 'mis-peptidome'on HLA class I-mediated diseases: contribution of ERAP1 and ERAP2 and effects on the immune response
V Tedeschi, G Paldino, F Paladini, B Mattorre… - International Journal of …, 2020 - mdpi.com
The strong association with the Major Histocompatibility Complex (MHC) class I genes
represents a shared trait for a group of autoimmune/autoinflammatory disorders having in …
represents a shared trait for a group of autoimmune/autoinflammatory disorders having in …
Biallelic AOPEP Loss‐of‐Function Variants Cause Progressive Dystonia with Prominent Limb Involvement
Background Monogenic causes of isolated dystonia are heterogeneous. Assembling cohorts
of affected individuals sufficiently large to establish new gene–disease relationships can be …
of affected individuals sufficiently large to establish new gene–disease relationships can be …
SARS-CoV-2 mutations affect antigen processing by the proteasome to alter CD8+ T cell responses
Mutations within viral epitopes can result in escape from T cells, but the contribution of
mutations in flanking regions of epitopes in SARS-CoV-2 has not been investigated …
mutations in flanking regions of epitopes in SARS-CoV-2 has not been investigated …
Lessons on SpA pathogenesis from animal models
M Breban, S Glatigny, B Cherqaoui… - Seminars in …, 2021 - Springer
Understanding the complex mechanisms underlying a disorder such as spondyloarthritis
(SpA) may benefit from studying animal models. Several suitable models have been …
(SpA) may benefit from studying animal models. Several suitable models have been …
ERAP2 is associated with immune infiltration and predicts favorable prognosis in SqCLC
Z Yang, H Tian, F Bie, J Xu, Z Zhou, J Yang… - Frontiers in …, 2021 - frontiersin.org
Background Immunotherapy has been proven effective among several human cancer types,
including Squamous cell lung carcinoma (SqCLC). ERAP2 plays a pivotal role in peptide …
including Squamous cell lung carcinoma (SqCLC). ERAP2 plays a pivotal role in peptide …
Whole-exome sequencing study identifies four novel gene loci associated with diabetic kidney disease
Diabetic kidney disease (DKD) is recognized as an important public health challenge.
However, its genomic mechanisms are poorly understood. To identify rare variants for DKD …
However, its genomic mechanisms are poorly understood. To identify rare variants for DKD …
[HTML][HTML] Shedding light on the role of ERAP1 in axial spondyloarthritis
MA Saad, AB Abdul-Sattar, IT Abdelal, A Baraka - Cureus, 2023 - ncbi.nlm.nih.gov
Spondyloarthritis (SpA) is a multifactorial chronic inflammatory disease affecting the axial
skeleton (axSpA) and/or peripheral joints (p-SpA) and entheses. The disease's …
skeleton (axSpA) and/or peripheral joints (p-SpA) and entheses. The disease's …