The role of collagen in cancer: from bench to bedside
S Xu, H Xu, W Wang, S Li, H Li, T Li, W Zhang… - Journal of translational …, 2019 - Springer
Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …
Adipose tissue: between the extremes
A Vegiopoulos, M Rohm, S Herzig - The EMBO journal, 2017 - embopress.org
Adipose tissue represents a critical component in healthy energy homeostasis. It fulfills
important roles in whole‐body lipid handling, serves as the body's major energy storage …
important roles in whole‐body lipid handling, serves as the body's major energy storage …
Cancer cachexia: more than skeletal muscle wasting
SF Schmidt, M Rohm, S Herzig, MB Diaz - Trends in cancer, 2018 - cell.com
Cancer cachexia is a multifactorial condition characterized by body weight loss that
negatively affects quality of life and survival of patients with cancer. Despite the clinical …
negatively affects quality of life and survival of patients with cancer. Despite the clinical …
[HTML][HTML] Contribution of adipose tissue to development of cancer
AJ Cozzo, AM Fuller, L Makowski - Comprehensive Physiology, 2017 - ncbi.nlm.nih.gov
Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding
tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell …
tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell …
The role of tumor microenvironment cells in colorectal cancer (CRC) cachexia
A Kasprzak - International journal of molecular sciences, 2021 - mdpi.com
Cancer cachexia (CC) is a multifactorial syndrome in patients with advanced cancer
characterized by weight loss via skeletal-muscle and adipose-tissue atrophy, catabolic …
characterized by weight loss via skeletal-muscle and adipose-tissue atrophy, catabolic …
An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia
H Xie, C Heier, X Meng, L Bakiri… - Proceedings of the …, 2022 - National Acad Sciences
Cancer-associated cachexia (CAC) is a hypermetabolic syndrome characterized by
unintended weight loss due to the atrophy of adipose tissue and skeletal muscle. A …
unintended weight loss due to the atrophy of adipose tissue and skeletal muscle. A …
Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia
J Taylor, L Uhl, I Moll, SS Hasan, L Wiedmann… - Nature Cancer, 2023 - nature.com
Cachexia is a major cause of morbidity and mortality in individuals with cancer and is
characterized by weight loss due to adipose and muscle tissue wasting. Hallmarks of white …
characterized by weight loss due to adipose and muscle tissue wasting. Hallmarks of white …
Perilipin 1 (Plin1) deficiency promotes inflammatory responses in lean adipose tissue through lipid dysregulation
Lipid droplets are specialized cellular organelles that contain neutral lipid metabolites and
play dynamic roles in energy homeostasis. Perilipin 1 (Plin1), one of the major lipid droplet …
play dynamic roles in energy homeostasis. Perilipin 1 (Plin1), one of the major lipid droplet …
Human cachexia induces changes in mitochondria, autophagy and apoptosis in the skeletal muscle
GS de Castro, E Simoes, JDCC Lima, M Ortiz-Silva… - Cancers, 2019 - mdpi.com
Cachexia is a wasting syndrome characterized by the continuous loss of skeletal muscle
mass due to imbalance between protein synthesis and degradation, which is related with …
mass due to imbalance between protein synthesis and degradation, which is related with …
Transforming growth factor-beta signaling in cancer-induced cachexia: from molecular pathways to the clinics
R Balsano, Z Kruize, M Lunardi, A Comandatore… - Cells, 2022 - mdpi.com
Cachexia is a metabolic syndrome consisting of massive loss of muscle mass and function
that has a severe impact on the quality of life and survival of cancer patients. Up to 20% of …
that has a severe impact on the quality of life and survival of cancer patients. Up to 20% of …