• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

In this scientific statement from the American Heart Association, experts in the field of
cardiomyopathy (heart muscle disease) in children address 2 issues: the most current …

Pediatric cardiomyopathies are rare diseases with an annual incidence of 1.1 to 1.5 per 100
000. Dilated and hypertrophic cardiomyopathies are the most common; restrictive …

Troponin T (TnT) is a central player in the calcium regulation of actin thin filament function
and is essential for the contraction of striated muscles. Three homologous genes have …

Hypertrophic cardiomyopathy (HCM) is the most-common monogenically inherited form of
heart disease, characterized by thickening of the left ventricular wall, contractile dysfunction …

Troponin (Tn) is a critical regulator of muscle contraction in cardiac muscle. Mutations in Tn
subunits are associated with hypertrophic, dilated and restrictive cardiomyopathies …

The sarcomere as the smallest contractile unit is prone to alterations in its functional,
structural and associated proteins. Sarcomeric dysfunction leads to heart failure or …

RASopathies are a family of developmental disorders that share germline mutations in the
components of the RAS-MAPK pathway leading to dysregulated signalling. A high …

Cardiomyopathy is defined as a disease of functional impairment in the cardiac muscle and
its etiology includes both extrinsic and intrinsic factors. Cardiomyopathy caused by the …

Restrictive cardiomyopathy (RCM) is the least frequent phenotype among pediatric heart
muscle diseases, representing only 2.5–3% of all cardiomyopathies diagnosed during …