T cell receptor signalling networks: branched, diversified and bounded
RJ Brownlie, R Zamoyska - Nature Reviews Immunology, 2013 - nature.com
Engagement of antigen-specific T cell receptors (TCRs) is a prerequisite for T cell activation.
Acquisition of appropriate effector T cell function requires the participation of multiple signals …
Acquisition of appropriate effector T cell function requires the participation of multiple signals …
Emerging possibilities in the development and function of regulatory T cells
K Wing, Z Fehérvári, S Sakaguchi - International immunology, 2006 - academic.oup.com
Abstract CD25+ CD4+ Regulatory T cells (Treg) represent a unique population of
lymphocytes capable of powerfully suppressing immune responses. A large body of …
lymphocytes capable of powerfully suppressing immune responses. A large body of …
Antibody molecules to PD-1 and uses thereof
GJ Freeman, AH Sharpe, WA Blattler… - US Patent …, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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Methods for treating cancer using anti-PD-1 antibodies
AJ Korman, M Srinivasan, C Wang, MJ Selby… - US Patent …, 2016 - Google Patents
The present invention provides isolated monoclonal antibodies, particularly human
monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid …
monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid …
Methods for treating cancer using anti-PD-1 antibodies
AJ Korman, M Srinivasan, C Wang, MJ Selby… - US Patent …, 2015 - Google Patents
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Immunopotentiative composition
T Honjo, N Minato, Y Iwai, S Shibayama - US Patent 9,073,994, 2015 - Google Patents
Compositions for cancer or infection treatment via immuno potentiation caused by inhibition
of immunosuppressive sig nal induced by PD-1, PD-L1, or PD-L2 and therapies using them …
of immunosuppressive sig nal induced by PD-1, PD-L1, or PD-L2 and therapies using them …
Immunopotentiative composition
T Honjo, N Minato, Y Iwai, S Shibayama - US Patent 9,067,999, 2015 - Google Patents
Compositions for cancer or infection treatment via immuno potentiation caused by inhibition
of immunosuppressive sig nal induced by PD-1, PD-L1, or PD-L2 and therapies using them …
of immunosuppressive sig nal induced by PD-1, PD-L1, or PD-L2 and therapies using them …
Monoclonal antibodies to programmed death 1 (PD-1)
AJ Korman, M Srinivasan, C Wang, MJ Selby… - US Patent …, 2016 - Google Patents
The present invention provides isolated monoclonal antibodies, particularly human
monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid …
monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid …
Immunopotentiative composition
T Honjo, N Minato, Y Iwai, S Shibayama - US Patent 9,402,899, 2016 - Google Patents
Related US Application Data (62) Division of application No. 12/959,307, filed on Dec. 2,
2010, now Pat. No. 8,728,474, which is a division of application No. 12/538,698, filed on …
2010, now Pat. No. 8,728,474, which is a division of application No. 12/538,698, filed on …
Monoclonal antibodies to Programmed Death 1 (PD-1)
AJ Korman, M Srinivasan, C Wang, MJ Selby… - US Patent …, 2016 - Google Patents
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