Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional
(3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues …

Extracellular vesicles (eg, exosomes) carrying various biomolecules (eg, proteins, lipids,
and nucleic acids) have rapidly emerged as promising platforms for many biomedical …

Background Scar formation is a common consequence of skin wound healing, and no
effective treatment exists. Umbilical cord blood mesenchymal stem cells (UCB-MSCs) can …

Doxorubicin (Dox) is an effective antineoplastic agent used to treat cancers, but its use is
limited as Dox induces adverse cardiotoxic effects. Dox-induced cardiotoxicity (DIC) can …

In the past decades, numerous preclinical studies and several clinical trials have evidenced
the feasibility of cell transplantation in treating heart diseases. Over the years, different …

Stem cell therapy has immense potential in a variety of regenerative medicine applications.
However, clinical stem cell therapy is severely limited by challenges in assessing the …

Myocardial ischemia/reperfusion (I/R) injury is the resultantly pathological heart damage
from the restoration of blood supply through percutaneous coronary intervention. Herein …

Cell-based therapies offer an exciting and novel treatment for heart repair following
myocardial infarction (MI). However, these therapies often suffer from poor cell viability and …

The field of extracellular vesicles has been rapidly developing after it became evident that a
defined subset of vesicles, called exosomes, can modulate several biological functions in …

Adult wound healing often results in fibrotic scarring that is caused by myofibroblast
aggregation. Human amniotic fluid stem cells (hAFSCs) exhibit significantly anti-fibrotic …