B cells are a major component of the tumour microenvironment, where they are
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …

IgG4 is the least abundant subclass of IgG in human serum and has unique functional
features. IgG4 is largely unable to activate antibody-dependent immune effector responses …

Recent data show that B cells and plasma cells located in tumours or in tumour-draining
lymph nodes can have important roles in shaping antitumour immune responses. In tumour …

Less than a year after the global emergence of the coronavirus SARS-CoV-2, a novel
vaccine platform based on mRNA technology was introduced to the market. Globally, around …

Tumor-infiltrating B cells (TIL-B) in breast cancer (BC) have previously been associated with
improved clinical outcomes; however, their roles in tumor immunity are not currently well …

Oncolytic herpes simplex virus-1 is capable of lysing tumor cells while alerting the immune
system. CD47, in collaboration with SIRPα, represents an important immune checkpoint to …

The overall objective of these guidelines is to provide evidence-based recommendations for
the diagnosis and management of immunoglobulin G4 (IgG4)-related digestive disease in …

B cells play a central role in the immune system through the production of antibodies. During
the past two decades, it has become increasingly clear that B cells also have the capacity to …

Primary tumors may create the premetastatic niche in secondary organs for subsequent
metastasis. Humoral immunity contributes to the progression of certain cancers, but the roles …

The human phase 2B RV144 ALVAC-HIV vCP1521/AIDSVAX B/E vaccine trial, held in
Thailand, resulted in an estimated 31.2% efficacy against HIV infection. By contrast …