Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Biomolecular condensates are micron-scale compartments in eukaryotic cells that lack
surrounding membranes but function to concentrate proteins and nucleic acids. These …

Cellular bodies such as P bodies and PML nuclear bodies (PML NBs) appear to be phase-
separated liquids organized by multivalent interactions among proteins and RNA molecules …

Biomolecular condensates (biocondensates) formed via liquid–liquid phase-separation of
soluble proteins have been studied extensively. However, neither the phase-separation of …

Liquid–liquid phase separation (LLPS) is thought to contribute to the establishment of many
biomolecular condensates, eukaryotic cell structures that concentrate diverse …

Stress granules (SGs) are cytoplasmic aggregates of stalled translational preinitiation
complexes that accumulate during stress. GW bodies/processing bodies (PBs) are distinct …

In senescent cells, specialized domains of transcriptionally silent senescence-associated
heterochromatic foci (SAHF), containing heterochromatin proteins such as HP1, are thought …

Cells contain numerous, molecularly distinct cellular compartments that are not enclosed by
lipid bilayers. These compartments are implicated in a wide range of cellular activities, and …

TAR DNA-binding protein-43 (TDP-43), a DNA/RNA-binding protein involved in RNA
transcription and splicing, has been associated with the pathophysiology of …

Nucleoli are the prominent contrasted structures of the cell nucleus. In the nucleolus,
ribosomal RNAs are synthesized, processed and assembled with ribosomal proteins. RNA …