Ammonia is constantly produced as a metabolic waste from amino acid catabolism in
mammals. Ammonia, the toxic waste metabolite, is resolved in the liver where the urea cycle …

Hyperammonemia occurs frequently in the critically ill but is largely confined to patients with
hepatic dysfunction or failure. Non-hepatic hyperammonemia (NHHA) is far less common …

Objectives: To evaluate the epidemiology of hyperammonemia unrelated to liver failure in
the critical care setting. Design: Retrospective case series. Setting: Critically ill patients …

Hepatic encephalopathy (HE) is a serious neuropsychiatric complication that occurs as a
result of liver failure. Umbelliferone (UMB; 7-hydroxycoumarin) is a natural product with …

Background Hyperammonemia caused by a disorder of the urea cycle is a rare cause of
metabolic encephalopathy that may be underdiagnosed by the adult intensivists because of …

Hyperammonaemia (HA) as a consequence of numerous primary or secondary causes,
gives rise to clinical manifestations due to its toxic effects on the brain. The neurological …

Normothermic machine perfusion (NMP) is emerging as a novel preservation strategy.
During NMP, the organ is maintained in a metabolically active state that may not only …

Hyperammonemia is the pathological accumulation of ammonia in the blood, which can
occur in many different clinical settings. Most commonly in adults, hyperammonemia occurs …

Hepatic encephalopathy (HE) is a severe metabolic syndrome linked with acute/chronic
hepatic disorders. HE is also a pernicious neuropsychiatric complication associated with …

For nearly 30 years, Principles of Medical Biochemistry has integrated medical biochemistry
with molecular genetics, cell biology, and genetics to provide complete yet concise coverage …