[HTML][HTML] TNFSF14: LIGHTing the way for effective cancer immunotherapy
Tumor necrosis factor superfamily member 14 (LIGHT) has been in pre-clinical development
for over a decade and shows promise as a modality of enhancing treatment approaches in …
for over a decade and shows promise as a modality of enhancing treatment approaches in …
[HTML][HTML] Detection of COVID-19-related biomarkers by electrochemical biosensors and potential for diagnosis, prognosis, and prediction of the course of the disease in …
V Vásquez, J Orozco - Analytical and bioanalytical chemistry, 2023 - Springer
As a more efficient and effective way to address disease diagnosis and intervention, cutting-
edge technologies, devices, therapeutic approaches, and practices have emerged within the …
edge technologies, devices, therapeutic approaches, and practices have emerged within the …
Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans
Coronavirus disease 2019 (COVID-19) represents a global crisis, yet major knowledge gaps
remain about human immunity to severe acute respiratory syndrome coronavirus 2 (SARS …
remain about human immunity to severe acute respiratory syndrome coronavirus 2 (SARS …
[HTML][HTML] Autoantibodies against ACE2 and angiotensin type-1 receptors increase severity of COVID-19
AI Rodriguez-Perez, CM Labandeira, MA Pedrosa… - Journal of …, 2021 - Elsevier
The renin-angiotensin system (RAS) plays a major role in COVID-19. Severity of several
inflammation-related diseases has been associated with autoantibodies against RAS …
inflammation-related diseases has been associated with autoantibodies against RAS …
[HTML][HTML] Realigning the LIGHT signaling network to control dysregulated inflammation
CF Ware, M Croft, GA Neil - The Journal of Experimental Medicine, 2022 - ncbi.nlm.nih.gov
Advances in understanding the physiologic functions of the tumor necrosis factor
superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper …
superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper …
[HTML][HTML] Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors
Y Huang, Y Chen, S Zhou, L Chen, J Wang… - Nature …, 2020 - nature.com
The failure of immunotherapies in immune-excluded tumor (IET) is largely ascribed to the
void of intratumoral cytotoxic T cells (CTLs). The major obstacles are the excessive stroma …
void of intratumoral cytotoxic T cells (CTLs). The major obstacles are the excessive stroma …
[HTML][HTML] The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases
K Wojciechowicz, M Spodzieja, KA Lisowska… - Cellular …, 2022 - Elsevier
Autoimmune diseases constitute a heterogeneous group of disorders with one common
feature–the loss of immune tolerance towards autoantigens. Due to the complexity of the …
feature–the loss of immune tolerance towards autoantigens. Due to the complexity of the …
[HTML][HTML] TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation
Y Wu, S Zhan, L Chen, M Sun, M Li, X Mou… - Journal of Translational …, 2023 - Springer
Background Tumour necrosis factor superfamily protein 14 (TNFSF14), also called LIGHT, is
an important regulator of immunological and fibrosis diseases. However, its specific …
an important regulator of immunological and fibrosis diseases. However, its specific …
A deficiency in the cytokine TNFSF14/LIGHT limits inflammation and remodeling in murine eosinophilic esophagitis
MC Manresa, H Miki, J Miller, K Okamoto… - The Journal of …, 2022 - journals.aai.org
Eosinophilic esophagitis (EoE) is a chronic type 2 allergic disease, with esophageal tissue
remodeling as the mechanism behind clinical dysphagia and strictures. IL-13 is thought to …
remodeling as the mechanism behind clinical dysphagia and strictures. IL-13 is thought to …
Increased production of LIGHT by T cells in eosinophilic esophagitis promotes differentiation of esophageal fibroblasts toward an inflammatory phenotype
MC Manresa, AWT Chiang, RC Kurten, R Dohil… - Gastroenterology, 2020 - Elsevier
Background & Aims Eosinophilic esophagitis (EoE) is an antigen-mediated eosinophilic
disease of the esophagus that involves fibroblast activation and progression to fibrostenosis …
disease of the esophagus that involves fibroblast activation and progression to fibrostenosis …