Interferons are a group of immunomodulatory substances produced by the human immune
system in response to the presence of pathogens, especially during viral and bacterial …

Defensins are antimicrobial peptides that participate in the innate immunity of hosts.
Humans constitutively and/or inducibly express α-and β-defensins, which are known for their …

Mutant KRAS tumors are associated with poor outcomes, at least in part, due to decreased
therapeutic sensitivity. Here, we show that KRAS mutations are associated with resistance to …

IFI44 is an interferon-alfa inducible protein, and is associated with infection of several
viruses. However, IFI44 elicits minimal antiviral effects on these viruses, and its exact role is …

Purpose The incomplete immune reconstitution is a complex phenomenon among human
immunodeficiency virus (HIV)-infected patients despite the fact that they have achieved …

Background Disease progression in the absence of therapy varies significantly in HIV-1
infected individuals. Both viral and host cellular molecules are implicated; however, the …

The mammalian host responds to viral infections by inducing expression of hundreds of
interferon-stimulated genes (ISGs). While the functional significance of many ISGs has yet to …

Cannabis (Cannabis sativa) is a widely used drug in the United States and the frequency of
cannabis use is particularly high among people living with HIV (PLWH). One key component …

Increasing numbers of SARS-CoV-2-positive (SARS-CoV-2pos) subjects are detected at
silent SARS-CoV-2 infection stage (SSIS). Yet, SSIS represents a poorly examined time …

ABSTRACT HIV establishes long-term latent infection in memory CD4+ T cells and also
establishes sustained long-term productive infection in macrophages, especially in the …